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    hadh hydroxyacyl-CoA dehydrogenase [ Danio rerio (zebrafish) ]

    Gene ID: 445121, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hadhprovided by ZNC
    Official Full Name
    hydroxyacyl-CoA dehydrogenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-261
    See related
    Ensembl:ENSDARG00000030765 AllianceGenome:ZFIN:ZDB-GENE-040801-261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hoad; hadhsc; zgc:86777; wu:fb66a11
    Summary
    Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in intestine and liver. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hadh in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (49909672..49918867, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (49265846..49275041, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495292 Neighboring gene lymphoid enhancer-binding factor 1 Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene cytochrome P450, family 2, subfamily U, polypeptide 1 Neighboring gene sphingomyelin synthase 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
    2. Cardiac and Metabolic Effects of Dietary Selenomethionine Exposure in Adult Zebrafish. Pettem CM, et al. Toxicol Sci, 2017 Oct 1. PMID 28962524
    3. Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). McClelland GB, et al. J Physiol, 2006 Dec 1. PMID 16990399, Free PMC Article
    4. Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. Kurchaba N, et al. Am J Physiol Regul Integr Comp Physiol, 2022 Sep 1. PMID 35670765
    5. Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. Qiu W, et al. Sci Total Environ, 2020 May 10. PMID 32036144

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
    Names
    L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
    hydroxyacyl-Coenzyme A dehydrogenase
    NP_001003515.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003515.1 → NP_001003515.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_001003515.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075768
      UniProtKB/TrEMBL
      A0A8M1N163, Q6DI22
      Related
      ENSDARP00000050602.5, ENSDART00000050603.6
      Conserved Domains (3) summary
      COG1250
      Location:20 → 307
      FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
      pfam00725
      Location:211 → 308
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:24 → 209
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      49909672..49918867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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