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    agla amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a [ Danio rerio (zebrafish) ]

    Gene ID: 567798, updated on 17-Aug-2024

    Summary

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    Official Symbol
    aglaprovided by ZNC
    Official Full Name
    amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071004-6
    See related
    Ensembl:ENSDARG00000103811 AllianceGenome:ZFIN:ZDB-GENE-071004-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    agl; si:ch211-153l6.1
    Summary
    Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Predicted to act upstream of or within glycogen biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20472102..20526835)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (20814143..20868863)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch211-153l6.6 Neighboring gene uncharacterized LOC108179662 Neighboring gene ferric-chelate reductase 1a Neighboring gene si:ch73-14h1.2 Neighboring gene si:ch211-267e7.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. Quach HN, et al. G3 (Bethesda), 2015 Apr 2. PMID 25840430, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-alpha-glucanotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-maltose 4-alpha-glucanotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycogen debranching enzyme
    Names
    amylo-1, 6-glucosidase, 4-alpha-glucanotransferase a
    NP_001166124.1
    XP_005163674.1
    XP_005163675.1
    XP_009296758.1
    XP_009296759.1
    XP_009296760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172653.1 → NP_001166124.1  glycogen debranching enzyme

      Status: VALIDATED

      Source sequence(s)
      BX510644, CU928067
      UniProtKB/TrEMBL
      A0A0R4IV67, A0A8M1NUM0
      Related
      ENSDARP00000138992.1, ENSDART00000168537.2
      Conserved Domains (5) summary
      cd11327
      Location:105 → 583
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:21 → 1532
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1073 → 1527
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:30 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:697 → 974
      hGDE_central; central domain of human glycogen debranching enzyme

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      20472102..20526835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163617.3 → XP_005163674.1  glycogen debranching enzyme isoform X2

      UniProtKB/TrEMBL
      A0A8M2BAR0
      Conserved Domains (5) summary
      cd11327
      Location:105 → 584
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:21 → 1533
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1074 → 1528
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:30 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:698 → 975
      hGDE_central; central domain of human glycogen debranching enzyme

    2. XM_005163618.3 → XP_005163675.1  glycogen debranching enzyme isoform X1

      See identical proteins and their annotated locations for XP_005163675.1

      UniProtKB/TrEMBL
      A0A8M3AQ64
      Conserved Domains (5) summary
      cd11327
      Location:105 → 584
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:21 → 1533
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1074 → 1528
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:30 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:698 → 975
      hGDE_central; central domain of human glycogen debranching enzyme

    3. XM_009298485.3 → XP_009296760.1  glycogen debranching enzyme isoform X1

      See identical proteins and their annotated locations for XP_009296760.1

      UniProtKB/TrEMBL
      A0A8M3AQ64
      Conserved Domains (5) summary
      cd11327
      Location:105 → 584
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:21 → 1533
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1074 → 1528
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:30 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:698 → 975
      hGDE_central; central domain of human glycogen debranching enzyme

    4. XM_009298484.3 → XP_009296759.1  glycogen debranching enzyme isoform X1

      See identical proteins and their annotated locations for XP_009296759.1

      UniProtKB/TrEMBL
      A0A8M3AQ64
      Conserved Domains (5) summary
      cd11327
      Location:105 → 584
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:21 → 1533
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1074 → 1528
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:30 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:698 → 975
      hGDE_central; central domain of human glycogen debranching enzyme

    5. XM_009298483.3 → XP_009296758.1  glycogen debranching enzyme isoform X1

      See identical proteins and their annotated locations for XP_009296758.1

      UniProtKB/TrEMBL
      A0A8M3AQ64
      Conserved Domains (5) summary
      cd11327
      Location:105 → 584
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:21 → 1533
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1074 → 1528
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:30 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:698 → 975
      hGDE_central; central domain of human glycogen debranching enzyme
    Nucleotide Protein
    Heading Accession and Version

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