plaua plasminogen activator, urokinase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plauaprovided by ZNC
Official Full Name: plasminogen activator, urokinase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-278
See related: Ensembl:ENSDARG00000075265 AllianceGenome:ZFIN:ZDB-GENE-090313-278
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-252g6.1
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within plasminogen activation. Predicted to be active in extracellular space. Is expressed in several structures, including eye; gill; gonad; heart; and liver. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (25297257..25305179, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (25166807..25174729, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj26e03.y1 (e-PCR)
- UniSTS:198914

fk07g01.x1 (e-PCR)
- UniSTS:200540

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestion	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plasminogen activator, urokinase a; urokinase-type plasminogen activator

NP_001165872.1

EC 3.4.21.73

XP_017214157.1

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172401.1 → NP_001165872.1 plasminogen activator, urokinase a precursor

See identical proteins and their annotated locations for NP_001165872.1

Status: PROVISIONAL

Source sequence(s)

FJ660930

UniProtKB/TrEMBL

A0A8M1NVU5, D3GE88

Related

ENSDARP00000100380.2, ENSDART00000110064.4

Conserved Domains (3) summary

smart00020
Location:144 → 383

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:145 → 386

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl00100
Location:37 → 111

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...