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    mhc1zca major histocompatibility complex class I ZCA [ Danio rerio (zebrafish) ]

    Gene ID: 556341, updated on 17-Aug-2024

    Summary

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    Official Symbol
    mhc1zcaprovided by ZNC
    Official Full Name
    major histocompatibility complex class I ZCAprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070424-4
    See related
    Ensembl:ENSDARG00000069471 AllianceGenome:ZFIN:ZDB-GENE-070424-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dZ63M10.1; zgc:111893; zgc:136614; si:ch211-287j19.5
    Summary
    Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to several human genes including AZGP1 (alpha-2-glycoprotein 1, zinc-binding); HFE (homeostatic iron regulator); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (47140787..47151827, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (46449556..46460570, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex class I ZEA Neighboring gene major histocompatibility complex class I ZDA Neighboring gene uncharacterized LOC103909196 Neighboring gene major histocompatibility complex class I ZBA Neighboring gene carbonyl reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Honjo Y, et al. Dev Comp Immunol, 2021 Mar. PMID 33279476
    2. Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Dirscherl H, et al. Immunogenetics, 2014 Mar. PMID 24287892, Free PMC Article
    3. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. McConnell SC, et al. Immunogenetics, 2014 Mar. PMID 24291825, Free PMC Article
    4. A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Dirscherl H, et al. Immunogenetics, 2015 Sep. PMID 26254596, Free PMC Article
    5. The MHC class I genes of zebrafish. Dirscherl H, et al. Dev Comp Immunol, 2014 Sep. PMID 24631581, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC111893

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major histocompatibility complex class I ZCA; uncharacterized protein LOC556341
    Names
    MHC class I antigen ZCA
    dZ63M10.1 (novel MHC class I antigen)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083545.1 → NP_001077014.1  major histocompatibility complex class I ZCA precursor

      See identical proteins and their annotated locations for NP_001077014.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115196
      UniProtKB/TrEMBL
      A4FUM4, U6BRB7
      Related
      ENSDARP00000063528.6, ENSDART00000063529.8
      Conserved Domains (2) summary
      cd07698
      Location:209 → 303
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:22 → 205
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      47140787..47151827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474930.1 → XP_021330605.1  uncharacterized protein LOC556341 isoform X1

      UniProtKB/TrEMBL
      F1QEW6, U6BNA4
      Related
      ENSDARP00000039383.7, ENSDART00000039459.8
      Conserved Domains (1) summary
      cl08246
      Location:22 → 205
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RNA

    1. XR_002458102.1 RNA Sequence

    2. XR_002458104.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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