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    erap1b endoplasmic reticulum aminopeptidase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 393175, updated on 27-Mar-2024

    Summary

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    Official Symbol
    erap1bprovided by ZNC
    Official Full Name
    endoplasmic reticulum aminopeptidase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-934
    See related
    Ensembl:ENSDARG00000021859 AllianceGenome:ZFIN:ZDB-GENE-040426-934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ARTS-1; zgc:56194
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See erap1b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26234404..26247688, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25634269..25647518, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene occludin b Neighboring gene general transcription factor IIH, polypeptide 2 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene ARVCF delta catenin family member b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56194

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum aminopeptidase 1; endoplasmic reticulum aminopeptidase 1b
    Names
    type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
    NP_956500.2
    XP_005171857.1
    XP_009299728.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200206.2 → NP_956500.2  endoplasmic reticulum aminopeptidase 1b precursor

      Status: VALIDATED

      Source sequence(s)
      BX510923
      UniProtKB/TrEMBL
      A0A8M1PE71
      Related
      ENSDARP00000115928.1, ENSDART00000145187.3
      Conserved Domains (3) summary
      cd09601
      Location:54 → 548
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:46 → 453
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:615 → 932
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      26234404..26247688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171800.4 → XP_005171857.1  endoplasmic reticulum aminopeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_005171857.1

      UniProtKB/TrEMBL
      A0A8M3B9L5, F1QFR6
      Conserved Domains (3) summary
      cd09601
      Location:54 → 528
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:46 → 433
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:595 → 912
      ERAP1_C; ERAP1-like C-terminal domain

    2. XM_009301453.3 → XP_009299728.1  endoplasmic reticulum aminopeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_009299728.1

      UniProtKB/TrEMBL
      A0A8M3B9L5, F1QFR6
      Related
      ENSDARP00000089298.4, ENSDART00000098527.6
      Conserved Domains (3) summary
      cd09601
      Location:54 → 528
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:46 → 433
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:595 → 912
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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