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    tspy testis specific protein Y-linked [ Danio rerio (zebrafish) ]

    Gene ID: 337214, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tspyprovided by ZNC
    Official Full Name
    testis specific protein Y-linkedprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9158
    See related
    Ensembl:ENSDARG00000005015 AllianceGenome:ZFIN:ZDB-GENE-030131-9158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56623; zgc:66430; wu:fb02c08
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Acts upstream of or within heart morphogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gonadal dysgenesis; prostate cancer; and sudden infant death syndrome. Orthologous to several human genes including TSPYL1 (TSPY like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See tspy in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (25708067..25716077, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (25688928..25696935, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene WASP actin nucleation promoting factor a Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga Neighboring gene forkhead box P3a Neighboring gene SUV39H1 histone lysine methyltransferase b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Unravelling the disease mechanism for TSPYL1 deficiency. Buyse G, et al. Hum Mol Genet, 2020 Dec 18. PMID 33075815
    2. Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. He Z, et al. Biochem Biophys Res Commun, 2019 Sep 10. PMID 31349972, Free PMC Article
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56623

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis specific protein Y-linked

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200055.1 → NP_956349.1  testis specific protein Y-linked

      See identical proteins and their annotated locations for NP_956349.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057534
      UniProtKB/TrEMBL
      A0A8N1TV92, Q6PFI8
      Related
      ENSDARP00000003150.8, ENSDART00000007482.9
      Conserved Domains (1) summary
      cl08298
      Location:227 → 403
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      25708067..25716077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167018.4 → XP_005167075.1  testis specific protein Y-linked isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEB9
      Conserved Domains (1) summary
      cl08298
      Location:227 → 403
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein Strain
    Heading Accession and Version

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