uspl1 ubiquitin specific peptidase like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uspl1provided by ZNC
Official Full Name: ubiquitin specific peptidase like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040930-7
See related: Ensembl:ENSDARG00000034825 AllianceGenome:ZFIN:ZDB-GENE-040930-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: c13orf22l
Summary: Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in Cajal body organization; protein desumoylation; and protein localization to Cajal body. Located in Cajal body. Orthologous to human USPL1 (ubiquitin specific peptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (36439276..36455985)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (36495535..36512205)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USPL1 depletion causes striking coilin mislocalization.
Title: Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SUMO binding	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO binding	IDA Inferred from Direct Assay more info	PubMed
enables SUMO binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Cajal body organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Cajal body organization	IEA Inferred from Electronic Annotation more info
involved_in Cajal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to Cajal body	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUMO-specific isopeptidase USPL1

Names: c13orf22 homolog, like; ubiquitin-specific peptidase-like protein 1

NP_001003880.1

EC 3.4.22.-

XP_021334834.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003880.1 → NP_001003880.1 SUMO-specific isopeptidase USPL1

See identical proteins and their annotated locations for NP_001003880.1

Status: PROVISIONAL

Source sequence(s)

AY648834

UniProtKB/Swiss-Prot

A8WFQ9, B0JZK5, Q6DRC5

Related

ENSDARP00000043801.4, ENSDART00000043802.5

Conserved Domains (1) summary

pfam15499
Location:356 → 634

Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

36439276..36455985

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479159.1 → XP_021334834.1 SUMO-specific isopeptidase USPL1 isoform X1

UniProtKB/TrEMBL

A0A8M9QC20

Conserved Domains (2) summary

pfam15499
Location:367 → 645

Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

cl28246
Location:111 → 322

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]