tada2b transcriptional adaptor 2B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tada2bprovided by ZNC
Official Full Name: transcriptional adaptor 2Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-557
See related: Ensembl:ENSDARG00000003769 AllianceGenome:ZFIN:ZDB-GENE-050522-557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb72h11; wu:fi12b07; wu:fi33a06; zgc:110397
Summary: Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling; positive regulation of histone acetylation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of histone acetylation. Predicted to be part of SAGA-type complex. Predicted to be active in nucleus. Is expressed in female organism. Orthologous to human TADA2B (transcriptional adaptor 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (39738505..39741732)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (39467488..39470715)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi89g08.x1 (e-PCR)
- UniSTS:198186

fb72h11.x1 (e-PCR)
- UniSTS:191131

fi12b07.x1 (e-PCR)
- UniSTS:204452

fi33a06.x1 (e-PCR)
- UniSTS:197297

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcriptional adapter 2-beta

Names: transcriptional adaptor 2 (ADA2 homolog, yeast)-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024443.1 → NP_001019614.1 transcriptional adapter 2-beta

See identical proteins and their annotated locations for NP_001019614.1

Status: PROVISIONAL

Source sequence(s)

BC095241

UniProtKB/Swiss-Prot

B5DDS4, Q503N9, Q7SXK2

Related

ENSDARP00000012853.6, ENSDART00000004365.8

Conserved Domains (3) summary

COG5114
Location:6 → 481

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:70 → 113

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:7 → 54

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.