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    serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 359841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    serpind1provided by ZNC
    Official Full Name
    serpin peptidase inhibitor, clade D (heparin cofactor), member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030711-2
    See related
    Ensembl:ENSDARG00000021208 AllianceGenome:ZFIN:ZDB-GENE-030711-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    HCII
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within blood coagulation. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See serpind1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (1766217..1781733)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (1760965..1776527)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene rasGAP-activating-like protein 1 Neighboring gene phosphatidylinositol 4-kinase, catalytic, alpha b Neighboring gene uncharacterized LOC137496286 Neighboring gene synaptosome associated protein 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor. Wu TS, et al. Chemosphere, 2020 Mar. PMID 31675585
    2. Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella). Chen L, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30439497
    3. Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish. Estepa A, et al. Fish Shellfish Immunol, 2015 Nov. PMID 26363229, Free PMC Article
    4. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Li Q, et al. Dis Model Mech, 2011 Nov. PMID 21816950, Free PMC Article
    5. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. Lopez-Rivera E, et al. N Engl J Med, 2017 Feb 23. PMID 28121514, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparin cofactor 2
    Names
    serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182880.1 → NP_878300.1  heparin cofactor 2 precursor

      See identical proteins and their annotated locations for NP_878300.1

      Status: PROVISIONAL

      Source sequence(s)
      AF515273
      UniProtKB/TrEMBL
      Q8AYE2
      Related
      ENSDARP00000073528.4, ENSDART00000079073.7
      Conserved Domains (1) summary
      cd02047
      Location:61 → 505
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      1766217..1781733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166737.5 → XP_005166794.1  heparin cofactor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BE52, B0V3R7
      Related
      ENSDARP00000017995.7, ENSDART00000021820.9
      Conserved Domains (1) summary
      cd02047
      Location:61 → 505
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

    2. XM_068222887.1 → XP_068078988.1  heparin cofactor 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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