bmi1a bmi1 polycomb ring finger oncogene 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmi1aprovided by ZNC
Official Full Name: bmi1 polycomb ring finger oncogene 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-224
See related: Ensembl:ENSDARG00000006010 AllianceGenome:ZFIN:ZDB-GENE-030131-224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bmi1; psc1; pcgf4; wu:fb17g03; wu:fd18f06
Summary: Predicted to enable promoter-specific chromatin binding activity. Acts upstream of or within cerebellum development; hematopoietic stem cell migration; and primitive hemopoiesis. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in eye; gonad; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (17260399..17267235)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (17115980..17122816)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer.
Title: Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer.
Bmi1 acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Title: Dominant-negative C/ebpα and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis.
10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. Cell growth maintenance, segment specification.
Title: Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polycomb complex protein BMI-1-A

Names: B lymphoma Mo-MLV insertion region 1 homolog; B lymphoma Mo-MLV insertion region 1a; polycomb group RING finger protein 4-A; polycomb group ring finger 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194366.1 → NP_919347.1 polycomb complex protein BMI-1-A

See identical proteins and their annotated locations for NP_919347.1

Status: PROVISIONAL

Source sequence(s)

AB074153

UniProtKB/Swiss-Prot

Q7ZWG4, Q8JIR0

UniProtKB/TrEMBL

A0A0R4I9F7

Related

ENSDARP00000106943.2, ENSDART00000129554.4

Conserved Domains (3) summary

TIGR00599
Location:10 → 201

rad18; DNA repair protein rad18

pfam00097
Location:20 → 58

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam16207
Location:152 → 226

RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like