aqp3a aquaporin 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aqp3aprovided by ZNC
Official Full Name: aquaporin 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2826
See related: Ensembl:ENSDARG00000003808 AllianceGenome:ZFIN:ZDB-GENE-040426-2826
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: aqp3; zgc:55525; wu:fa95h06; wu:fi13e05
Summary: Enables several functions, including arsenite transmembrane transporter activity; glycerol transmembrane transporter activity; and water transmembrane transporter activity. Acts upstream of or within late stripe melanocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including EVL; digestive system; integument; nervous system; and pleuroperitoneal region. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (43006422..43011814)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (42406269..42411661)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mutated amino acid residues in the dominant alleles line the pore surface of Aqp3a and influence pore permeability.
Title: Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment.
Enhanced water and cryoprotectant permeability of porcine oocytes after artificial expression of human and zebrafish aquaporin-3 channels.
Title: Enhanced water and cryoprotectant permeability of porcine oocytes after artificial expression of human and zebrafish aquaporin-3 channels.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arsenite transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urea transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within late stripe melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aquaporin-3a

Names: aquaporin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213468.1 → NP_998633.1 aquaporin-3a

See identical proteins and their annotated locations for NP_998633.1

Status: PROVISIONAL

Source sequence(s)

BC044188

UniProtKB/TrEMBL

B2GP75, Q803U6

Related

ENSDARP00000018463.4, ENSDART00000009182.5

Conserved Domains (1) summary

cd00333
Location:23 → 266

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...