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    PSMA2 proteasome 20S subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 5683, updated on 9-Dec-2024

    Summary

    Official Symbol
    PSMA2provided by HGNC
    Official Full Name
    proteasome 20S subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:9531
    See related
    Ensembl:ENSG00000106588 MIM:176842; AllianceGenome:HGNC:9531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MU; HC3; PSC2; PMSA2
    Summary
    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in liver (RPKM 64.0), fat (RPKM 48.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PSMA2 in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (42916861..42932174, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43075002..43090304, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (42956460..42971773, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986735 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:42910171-42910751 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:42915433-42916364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42917594-42918115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42923371-42924173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42927975-42928518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42950498-42951195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42951196-42951892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25904 Neighboring gene chromosome 7 open reading frame 25 Neighboring gene serine-threonine kinase receptor-associated protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25905 Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene uncharacterized LOC105375253

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of proteasome (prosome, macropain) subunit, alpha type, 2 (PSMA2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
    tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
    tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
    tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
    Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
    integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    proteasome subunit alpha type-2
    Names
    alpha-2
    macropain subunit C3
    multicatalytic endopeptidase complex subunit C3
    proteasome (prosome, macropain) subunit, alpha type, 2
    proteasome component C3
    proteasome subunit HC3
    proteasome subunit alpha 2
    NP_002778.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002787.5NP_002778.1  proteasome subunit alpha type-2

      See identical proteins and their annotated locations for NP_002778.1

      Status: REVIEWED

      Source sequence(s)
      AC010132
      Consensus CDS
      CCDS5467.1
      UniProtKB/Swiss-Prot
      P25787, Q6ICS6, Q9BU45
      UniProtKB/TrEMBL
      A0A024RA52, Q53GF5
      Related
      ENSP00000223321.4, ENST00000223321.9
      Conserved Domains (1) summary
      cd03750
      Location:6231
      proteasome_alpha_type_2; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      42916861..42932174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      43075002..43090304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)