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    DBNL drebrin like [ Homo sapiens (human) ]

    Gene ID: 28988, updated on 27-Nov-2024

    Summary

    Official Symbol
    DBNLprovided by HGNC
    Official Full Name
    drebrin likeprovided by HGNC
    Primary source
    HGNC:HGNC:2696
    See related
    Ensembl:ENSG00000136279 MIM:610106; AllianceGenome:HGNC:2696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABP1; HIP55; SH3P7; HIP-55
    Summary
    Enables cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 54.1), spleen (RPKM 52.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DBNL in Genome Data Viewer
    Location:
    7p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44044702..44069456)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44203197..44227954)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44084301..44109055)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit J4 (pseudogene) Neighboring gene speedy/RINGO cell cycle regulator family member E1 Neighboring gene Sharpr-MPRA regulatory region 7454 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44070666-44070855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44075983-44076482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18138 Neighboring gene RAS p21 protein activator 4C, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:44084499-44084999 Neighboring gene long intergenic non-protein coding RNA 957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44099073-44099648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44099649-44100225 Neighboring gene microRNA 6837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25929 Neighboring gene phosphoglycerate mutase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44119156-44120063 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:44121903-44122403 Neighboring gene microRNA 6838 Neighboring gene DNA polymerase mu Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44140397-44140898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44140899-44141398 Neighboring gene AE binding protein 1 Neighboring gene microRNA 4649

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cadherin binding HDA PubMed 
    enables enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in podosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in podosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    drebrin-like protein
    Names
    HPK1-interacting protein of 55 kDa
    SH3 domain-containing protein 7
    actin-binding protein 1
    cervical SH3P7
    cervical mucin-associated protein
    drebrin-F
    src homology 3 domain-containing protein HIP-55

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014436.3NP_001014436.1  drebrin-like protein isoform b

      See identical proteins and their annotated locations for NP_001014436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      AC017116, AF077353, BC011677
      Consensus CDS
      CCDS34623.1
      UniProtKB/Swiss-Prot
      A4D2I9, B4DDP6, B4DEM2, C9J7P1, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72, Q9UJU6
      UniProtKB/TrEMBL
      B4DDD6
      Related
      ENSP00000411701.1, ENST00000448521.6
      Conserved Domains (3) summary
      cd11281
      Location:3138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:375428
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      cl27169
      Location:225374
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
    2. NM_001122956.2NP_001116428.1  drebrin-like protein isoform c

      See identical proteins and their annotated locations for NP_001116428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC017116, AK027367, BC011677, DC404852
      Consensus CDS
      CCDS47579.1
      UniProtKB/TrEMBL
      B4DDD6
      Related
      ENSP00000417653.1, ENST00000468694.5
      Conserved Domains (2) summary
      cd11281
      Location:3138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:384437
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    3. NM_001284313.2NP_001271242.1  drebrin-like protein isoform d

      See identical proteins and their annotated locations for NP_001271242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons, uses an alternate in-frame splice site and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform c.
      Source sequence(s)
      AC017116, AF218020, AK293698
      Consensus CDS
      CCDS64634.1
      UniProtKB/TrEMBL
      B4DUF9
      Related
      ENSP00000415173.1, ENST00000440166.5
      Conserved Domains (2) summary
      cd11960
      Location:272325
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      cl15697
      Location:135
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    4. NM_001284315.2NP_001271244.1  drebrin-like protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two exons and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus compared to isoform c.
      Source sequence(s)
      AC017116, AF218020, AK300630
      Consensus CDS
      CCDS64633.1
      UniProtKB/TrEMBL
      B4DUF9
      Related
      ENSP00000417749.2, ENST00000490734.6
      Conserved Domains (2) summary
      cd11960
      Location:281334
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      cl15697
      Location:1543
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    5. NM_001362723.2NP_001349652.1  drebrin-like protein isoform f

      Status: VALIDATED

      Source sequence(s)
      AC017116, AK027367, BC011677, DC404852, DT220937
      UniProtKB/TrEMBL
      B4DDD6
      Conserved Domains (2) summary
      cd11281
      Location:3138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:383436
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    6. NM_014063.7NP_054782.2  drebrin-like protein isoform a

      See identical proteins and their annotated locations for NP_054782.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
      Source sequence(s)
      AC017116, BC011677, DC404852
      Consensus CDS
      CCDS34622.1
      UniProtKB/TrEMBL
      B4DDD6
      Related
      ENSP00000419992.1, ENST00000494774.5
      Conserved Domains (2) summary
      cd11281
      Location:3138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:376429
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      44044702..44069456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      44203197..44227954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)