HTRA3 HtrA serine peptidase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HTRA3provided by HGNC
Official Full Name: HtrA serine peptidase 3provided by HGNC
Primary source: HGNC:HGNC:30406
See related: Ensembl:ENSG00000170801 MIM:608785; AllianceGenome:HGNC:30406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Prsp; Tasp
Summary: Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p16.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (8269754..8307098)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (8248531..8287062)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (8271481..8308825)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.
Title: HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.
A Pan-Cancer Analysis to Provide Insight into the Immunological Role and Prognostic Value of HTRA3.
Title: A Pan-Cancer Analysis to Provide Insight into the Immunological Role and Prognostic Value of HTRA3.
mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.
Title: mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.
Study on the Correlation between the Levels of HtrA3 and TGF-beta2 in Late Pregnancy and Preeclampsia.
Title: Study on the Correlation between the Levels of HtrA3 and TGF-β2 in Late Pregnancy and Preeclampsia.
Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase inflammatory response in hypoxia/reoxygenation HK2 Cells.
Title: Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase inflammatory response in hypoxia/reoxygenation HK2 Cells.
Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer.
Title: Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer.
Our study also reports an intricate ligand-induced allosteric switch, which redefines the existing hypothesis of HtrA3 activation besides opening up avenues for modulating protease activity favorably through suitable effector molecules.
Title: A distinct concerted mechanism of structural dynamism defines activity of human serine protease HtrA3.
HtrA3 isoforms stimulate drug-induced apoptotic death of lung cancer cells via XIAP cleavage.
Title: The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP).
This study reports allosteric modulation of Human HtrA3 (High temperature requirement protease A3) enzyme activity for the first time. A novel non-classical allosteric ligand binding pocket mediates allostery in HtrA3.
Title: Identification of a distal allosteric ligand binding pocket in HtrA3.
Low expression of HtrA3 at 15 weeks is associated with, and may be useful for, the early detection of late-onset preeclampsia development and small for gestational age birth.
Title: Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80395 (e-PCR)
- UniSTS:84561

MARC_28683-28684:1042822462:1 (e-PCR)
- UniSTS:269153

A007I17 (e-PCR)
- UniSTS:11908

WI-12525 (e-PCR)
- UniSTS:1270

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease HTRA3

Names: high-temperature requirement factor A3; pregnancy-related serine protease; probable serine protease HTRA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297559.3 → NP_001284488.1 serine protease HTRA3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001284488.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons, and contains an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus.

Source sequence(s)

AC113611, AW072765, AY280666, DN996853

Consensus CDS

CCDS75105.1

UniProtKB/Swiss-Prot

P83110

Related

ENSP00000371952.3, ENST00000382512.3

Conserved Domains (3) summary

pfam00219
Location:25 → 76

IGFBP; Insulin-like growth factor binding protein

pfam07648
Location:81 → 126

Kazal_2; Kazal-type serine protease inhibitor domain

pfam13365
Location:175 → 319

Trypsin_2; Trypsin-like peptidase domain
NM_053044.5 → NP_444272.1 serine protease HTRA3 isoform 1 precursor

See identical proteins and their annotated locations for NP_444272.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC113611, BC035717

Consensus CDS

CCDS3400.1

UniProtKB/Swiss-Prot

P83110, Q7Z7A2

Related

ENSP00000303766.2, ENST00000307358.7

Conserved Domains (4) summary

cd00987
Location:355 → 440

PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...

pfam00219
Location:25 → 76

IGFBP; Insulin-like growth factor binding protein

pfam07648
Location:81 → 126

Kazal_2; Kazal-type serine protease inhibitor domain

pfam13365
Location:175 → 319

Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

8269754..8307098

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011513596.4 → XP_011511898.1 serine protease HTRA3 isoform X1

Conserved Domains (3) summary

pfam00219
Location:25 → 76

IGFBP; Insulin-like growth factor binding protein

pfam07648
Location:81 → 126

Kazal_2; Kazal-type serine protease inhibitor domain

pfam13365
Location:175 → 319

Trypsin_2; Trypsin-like peptidase domain