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    PPP1R16A protein phosphatase 1 regulatory subunit 16A [ Homo sapiens (human) ]

    Gene ID: 84988, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PPP1R16Aprovided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 16Aprovided by HGNC
    Primary source
    HGNC:HGNC:14941
    See related
    Ensembl:ENSG00000160972 MIM:609172; AllianceGenome:HGNC:14941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYPT3
    Summary
    Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]
    Expression
    Broad expression in duodenum (RPKM 18.4), small intestine (RPKM 14.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP1R16A in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144477982..144502121)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145647722..145671886)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145703365..145727504)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TMEM276-ZFTRAF1 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145689275-145689888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145692087-145692923 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145698787-145699682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145699683-145700576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145701473-145702366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19696 Neighboring gene forkhead box H1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145709653-145710352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145710353-145711052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145715271-145715770 Neighboring gene uncharacterized LOC101928953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145725199-145725860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19697 Neighboring gene Sharpr-MPRA regulatory region 2015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145729171-145729831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145735245-145735868 Neighboring gene glutamic--pyruvic transaminase Neighboring gene major facilitator superfamily domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood. Burkhardt R, et al. PLoS Genet, 2015 Sep. PMID 26401656, Free PMC Article
    2. Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A. Yong J, et al. J Biol Chem, 2006 Oct 20. PMID 16920702
    3. Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity. Ruan Y, et al. J Biol Chem, 2011 Aug 19. PMID 21712390, Free PMC Article
    4. Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Skinner JA, et al. Biochem J, 2001 May 15. PMID 11336659, Free PMC Article
    5. Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma. Igci YZ, et al. Endocr Pathol, 2011 Jun. PMID 21509594

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPP1R16A gene expression is decreased in follicular variant of papillary thyroid carcinoma.
      Title: Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
    2. analysis of a novel mechanism for the phosphorylation of MYPT3 by PKA and activation of the catalytic activity through direct interaction of a central region of MYPT3 with its N-terminal region
      Title: Phosphorylation of myosin phosphatase targeting subunit 3 (MYPT3) and regulation of protein phosphatase 1 by protein kinase A.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14333

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 16A
    Names
    myosin phosphatase-targeting subunit 3
    protein phosphatase 1, regulatory (inhibitor) subunit 16A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329442.2 → NP_001316371.1  protein phosphatase 1 regulatory subunit 16A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AC084125, BC053506, DB457525, HY013777, HY168641
      Consensus CDS
      CCDS6429.1
      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34
      Conserved Domains (3) summary
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:75 → 101
      ANK; ANK repeat [structural motif]

    2. NM_001329443.2 → NP_001316372.1  protein phosphatase 1 regulatory subunit 16A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      BC053506, CN301973, DB457525, HY168641
      Consensus CDS
      CCDS6429.1
      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34
      Related
      ENSP00000391126.1, ENST00000435887.2
      Conserved Domains (3) summary
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:75 → 101
      ANK; ANK repeat [structural motif]

    3. NM_001329444.2 → NP_001316373.1  protein phosphatase 1 regulatory subunit 16A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      BC053506, BM761618, HY168641, HY176205
      Consensus CDS
      CCDS6429.1
      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34
      Conserved Domains (3) summary
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:75 → 101
      ANK; ANK repeat [structural motif]

    4. NM_001329445.2 → NP_001316374.1  protein phosphatase 1 regulatory subunit 16A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      BC053506, BM762557, HY168641
      Consensus CDS
      CCDS6429.1
      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34
      Conserved Domains (3) summary
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:75 → 101
      ANK; ANK repeat [structural motif]

    5. NM_032902.7 → NP_116291.1  protein phosphatase 1 regulatory subunit 16A

      See identical proteins and their annotated locations for NP_116291.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AC084125, BC053506, DB457525, HY050499, HY168641
      Consensus CDS
      CCDS6429.1
      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34
      Conserved Domains (3) summary
      cd00204
      Location:98 → 285
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:75 → 101
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144477982..144502121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422334.1 → XP_047278290.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    2. XM_047422350.1 → XP_047278306.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    3. XM_047422335.1 → XP_047278291.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    4. XM_047422341.1 → XP_047278297.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    5. XM_047422351.1 → XP_047278307.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    6. XM_047422331.1 → XP_047278287.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    7. XM_047422340.1 → XP_047278296.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    8. XM_047422347.1 → XP_047278303.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    9. XM_047422337.1 → XP_047278293.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    10. XM_047422345.1 → XP_047278301.1  protein phosphatase 1 regulatory subunit 16A isoform X3

      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34

    11. XM_047422336.1 → XP_047278292.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    12. XM_047422342.1 → XP_047278298.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    13. XM_047422349.1 → XP_047278305.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    14. XM_047422338.1 → XP_047278294.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    15. XM_047422343.1 → XP_047278299.1  protein phosphatase 1 regulatory subunit 16A isoform X3

      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34

    16. XM_047422332.1 → XP_047278288.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    17. XM_047422348.1 → XP_047278304.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    18. XM_047422339.1 → XP_047278295.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    19. XM_047422346.1 → XP_047278302.1  protein phosphatase 1 regulatory subunit 16A isoform X3

      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34

    20. XM_047422352.1 → XP_047278308.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145647722..145671886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361386.1 → XP_054217361.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    2. XM_054361399.1 → XP_054217374.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    3. XM_054361387.1 → XP_054217362.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    4. XM_054361392.1 → XP_054217367.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    5. XM_054361400.1 → XP_054217375.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    6. XM_054361384.1 → XP_054217359.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    7. XM_054361391.1 → XP_054217366.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    8. XM_054361396.1 → XP_054217371.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    9. XM_054361389.1 → XP_054217364.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    10. XM_054361395.1 → XP_054217370.1  protein phosphatase 1 regulatory subunit 16A isoform X3

      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34

    11. XM_054361388.1 → XP_054217363.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    12. XM_054361393.1 → XP_054217368.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    13. XM_054361398.1 → XP_054217373.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    14. XM_054361390.1 → XP_054217365.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    15. XM_054361394.1 → XP_054217369.1  protein phosphatase 1 regulatory subunit 16A isoform X3

      UniProtKB/Swiss-Prot
      D3DWM5, Q96I34

    16. XM_054361385.1 → XP_054217360.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    17. XM_054361397.1 → XP_054217372.1  protein phosphatase 1 regulatory subunit 16A isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96I34.1 GenPept UniProtKB/Swiss-Prot:Q96I34

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