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    NKAIN4 sodium/potassium transporting ATPase interacting 4 [ Homo sapiens (human) ]

    Gene ID: 128414, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NKAIN4provided by HGNC
    Official Full Name
    sodium/potassium transporting ATPase interacting 4provided by HGNC
    Primary source
    HGNC:HGNC:16191
    See related
    Ensembl:ENSG00000101198 MIM:612873; AllianceGenome:HGNC:16191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM77A; C20orf58; bA261N11.2
    Summary
    NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
    Expression
    Biased expression in brain (RPKM 15.5), kidney (RPKM 2.4) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See NKAIN4 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63240784..63254921, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65046799..65060428, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61872136..61885815, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61830673-61831272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61831273-61831874 Neighboring gene YTH N6-methyladenosine RNA binding protein F1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61857740-61858694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61862252-61863021 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:61863095-61864294 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61865058-61865253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61866073-61866674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61870596-61871096 Neighboring gene uncharacterized LOC124904950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61879175-61880007 Neighboring gene microRNA 3196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61880008-61880839 Neighboring gene baculoviral IAP repeat containing 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61883491-61883999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61885071-61885602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61885603-61886134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61889508-61890125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61891361-61891976 Neighboring gene uncharacterized LOC100192386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13151 Neighboring gene ARF GTPase activating protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61915538-61916038 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr20:61922048-61922671 and GRCh37_chr20:61922672-61923296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61924431-61924932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61924933-61925432 Neighboring gene microRNA 4326 Neighboring gene collagen type XX alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61952290-61952790

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    2. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
    3. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
    Names
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4
    Na+/K+ transporting ATPase interacting 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363718.1 → NP_001350647.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK126246, AL121827, BI918324, BJ991175, BM673598, HY107676
      Consensus CDS
      CCDS86967.1
      UniProtKB/TrEMBL
      J3JS66
      Related
      ENSP00000359336.1, ENST00000370313.5
      Conserved Domains (1) summary
      pfam05640
      Location:1 → 115
      NKAIN; Na,K-Atpase Interacting protein

    2. NM_001363747.1 → NP_001350676.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK126246, AL121827, BM673598, BP219020, HY107676
      Consensus CDS
      CCDS86968.1
      UniProtKB/TrEMBL
      A6NNM2
      Conserved Domains (1) summary
      pfam05640
      Location:1 → 144
      NKAIN; Na,K-Atpase Interacting protein

    3. NM_152864.4 → NP_690603.3  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_690603.3

      Status: VALIDATED

      Source sequence(s)
      AK126246, BG708360, BM673598
      Consensus CDS
      CCDS13514.1
      UniProtKB/Swiss-Prot
      Q4VXQ6, Q8IVV8, Q9BQU8, Q9BQU9
      UniProtKB/TrEMBL
      B3KWY5
      Related
      ENSP00000359340.3, ENST00000370316.8
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 206
      NKAIN; Na,K-Atpase Interacting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      63240784..63254921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027636.3 → XP_016883125.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      Conserved Domains (1) summary
      pfam05640
      Location:1 → 143
      NKAIN; Na,K-Atpase Interacting protein

    2. XM_047439871.1 → XP_047295827.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X4

      UniProtKB/TrEMBL
      A6NNM2
      Related
      ENSP00000359330.2, ENST00000370307.6

    3. XM_047439872.1 → XP_047295828.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    4. XM_005260192.3 → XP_005260249.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

      See identical proteins and their annotated locations for XP_005260249.1

      UniProtKB/TrEMBL
      B3KWY5
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 177
      NKAIN; Na,K-Atpase Interacting protein

    5. XM_011528527.3 → XP_011526829.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

      UniProtKB/TrEMBL
      B3KWY5
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 205
      NKAIN; Na,K-Atpase Interacting protein

    6. XM_011528529.4 → XP_011526831.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011526831.1

      Conserved Domains (1) summary
      pfam05640
      Location:1 → 143
      NKAIN; Na,K-Atpase Interacting protein

    7. XM_017027637.3 → XP_016883126.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      Conserved Domains (1) summary
      pfam05640
      Location:1 → 143
      NKAIN; Na,K-Atpase Interacting protein

    8. XM_011528528.4 → XP_011526830.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011526830.1

      Conserved Domains (1) summary
      pfam05640
      Location:1 → 143
      NKAIN; Na,K-Atpase Interacting protein

    9. XM_024451824.2 → XP_024307592.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

      Conserved Domains (1) summary
      pfam05640
      Location:1 → 143
      NKAIN; Na,K-Atpase Interacting protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65046799..65060428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322939.1 → XP_054178914.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X2

    2. XM_054322938.1 → XP_054178913.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X1

    3. XM_054322940.1 → XP_054178915.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVV8.2 GenPept UniProtKB/Swiss-Prot:Q8IVV8

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