STEAP1 STEAP family member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STEAP1provided by HGNC
Official Full Name: STEAP family member 1provided by HGNC
Primary source: HGNC:HGNC:11378
See related: Ensembl:ENSG00000164647 MIM:604415; AllianceGenome:HGNC:11378
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STEAP; PRSS24
Summary: This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 54.6), appendix (RPKM 20.3) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (90154469..90164827)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (91404904..91415261)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (89783783..89794141)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis.
Title: Six Transmembrane Epithelial Antigen 1 as a Prognostic Biomarker in Carcinomas: A Meta-Analysis.
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells.
Title: Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells.
Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
Title: Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells.
STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide.
Title: STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide.
The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
Title: The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
Title: Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
Clinical significance of STEAP1 extracellular vesicles in prostate cancer.
Title: Clinical significance of STEAP1 extracellular vesicles in prostate cancer.
Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing's Sarcoma.
Title: Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing's Sarcoma.
A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
Title: A research of STEAP1 regulated gastric cancer cell proliferation, migration and invasion in vitro and in vivos.
The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
Title: The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN106051 (e-PCR)
- UniSTS:430848

REN106055 (e-PCR)
- UniSTS:430852

ECD22912 (e-PCR)
- UniSTS:303897

ECD04407 (e-PCR)
- UniSTS:285479

ECD08271 (e-PCR)
- UniSTS:289319

ECD17804 (e-PCR)
- UniSTS:298816

RH94098 (e-PCR)
- UniSTS:91226

D7S723 (e-PCR)
- UniSTS:5218

ECD03690 (e-PCR)
- UniSTS:284770

ECD04726 (e-PCR)
- UniSTS:285797

ECD15572 (e-PCR)
- UniSTS:296589

ECD12060 (e-PCR)
- UniSTS:293093

ECD14640 (e-PCR)
- UniSTS:295660

ECD03587 (e-PCR)
- UniSTS:284668

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables ferric-chelate reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	TAS Traceable Author Statement more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: STEAP1 protein

Names: STEAP1 metalloreductase; metalloreductase STEAP1; six transmembrane epithelial antigen of the prostate 1; six-transmembrane epithelial antigen of prostate 1

NP_036581.1

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012449.3 → NP_036581.1 STEAP1 protein

Status: REVIEWED

Source sequence(s)

AC004969

Consensus CDS

CCDS5614.1

UniProtKB/Swiss-Prot

A4D1E0, O95034, Q9UHE8

Related

ENSP00000297205.2, ENST00000297205.7

Conserved Domains (1) summary

cl23723
Location:156 → 316

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...