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    Zgrf1 zinc finger, GRF-type containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71643, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Zgrf1provided by MGI
    Official Full Name
    zinc finger, GRF-type containing 1provided by MGI
    Primary source
    MGI:MGI:1918893
    See related
    Ensembl:ENSMUSG00000051278 AllianceGenome:MGI:1918893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930422G04Rik
    Summary
    Predicted to enable 5'-3' DNA helicase activity and RNA binding activity. Predicted to be involved in recombinational repair. Predicted to be located in nucleus. Is expressed in brain ventricular layer and nose. Orthologous to human ZGRF1 (zinc finger GRF-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 4.0), limb E14.5 (RPKM 2.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zgrf1 in Genome Data Viewer
    Location:
    3 G2; 3 56.54 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127347080..127411672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127553396..127618023)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene predicted gene, 51018 Neighboring gene microRNA 302d Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene microRNA 367 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene predicted gene, 40147 Neighboring gene neurogenin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-3' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription termination site sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in recombinational repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in recombinational repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    5'-3' DNA helicase ZGRF1
    Names
    GRF-type zinc finger domain-containing protein 1
    protein ZGRF1
    NP_932114.2
    XP_006502172.1
    XP_011238535.1
    XP_017175214.1
    XP_017175215.1
    XP_017175216.1
    XP_030108684.1
    XP_030108685.1
    XP_036019224.1
    XP_036019225.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197997.2 → NP_932114.2  5'-3' DNA helicase ZGRF1

      See identical proteins and their annotated locations for NP_932114.2

      Status: VALIDATED

      Source sequence(s)
      AK046429, BC079891, CO044435
      Consensus CDS
      CCDS51066.1
      UniProtKB/Swiss-Prot
      E9Q2K6, Q0VGT4
      UniProtKB/TrEMBL
      I3PQW4
      Related
      ENSMUSP00000044432.5, ENSMUST00000043108.9
      Conserved Domains (5) summary
      COG1112
      Location:1487 → 1837
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam06839
      Location:1109 → 1153
      zf-GRF; GRF zinc finger
      pfam10382
      Location:3 → 72
      DUF2439; Protein of unknown function (DUF2439)
      pfam13086
      Location:1376 → 1605
      AAA_11; AAA domain
      pfam13087
      Location:1616 → 1800
      AAA_12; AAA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127347080..127411672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319725.3 → XP_017175214.1  5'-3' DNA helicase ZGRF1 isoform X1

      UniProtKB/TrEMBL
      I3PQW4
      Conserved Domains (4) summary
      TIGR00376
      Location:1568 → 2003
      TIGR00376; DNA helicase, putative
      pfam06839
      Location:1267 → 1311
      zf-GRF; GRF zinc finger
      pfam10382
      Location:3 → 75
      DUF2439; Protein of unknown function (DUF2439)
      pfam13087
      Location:1774 → 1981
      AAA_12; AAA domain

    2. XM_017319726.3 → XP_017175215.1  5'-3' DNA helicase ZGRF1 isoform X3

      UniProtKB/TrEMBL
      I3PQW4
      Conserved Domains (4) summary
      TIGR00376
      Location:1410 → 1845
      TIGR00376; DNA helicase, putative
      pfam06839
      Location:1109 → 1153
      zf-GRF; GRF zinc finger
      pfam10382
      Location:3 → 75
      DUF2439; Protein of unknown function (DUF2439)
      pfam13087
      Location:1616 → 1823
      AAA_12; AAA domain

    3. XM_030252824.2 → XP_030108684.1  5'-3' DNA helicase ZGRF1 isoform X6

      Conserved Domains (3) summary
      TIGR00376
      Location:542 → 977
      TIGR00376; DNA helicase, putative
      pfam06839
      Location:241 → 285
      zf-GRF; GRF zinc finger
      pfam13087
      Location:748 → 955
      AAA_12; AAA domain

    4. XM_006502109.5 → XP_006502172.1  5'-3' DNA helicase ZGRF1 isoform X2

      UniProtKB/TrEMBL
      I3PQW4
      Conserved Domains (4) summary
      TIGR00376
      Location:1568 → 1980
      TIGR00376; DNA helicase, putative
      pfam06839
      Location:1267 → 1311
      zf-GRF; GRF zinc finger
      pfam10382
      Location:3 → 75
      DUF2439; Protein of unknown function (DUF2439)
      pfam13087
      Location:1774 → 1958
      AAA_12; AAA domain

    5. XM_011240233.4 → XP_011238535.1  5'-3' DNA helicase ZGRF1 isoform X4

      Conserved Domains (1) summary
      pfam10382
      Location:3 → 75
      DUF2439; Protein of unknown function (DUF2439)

    6. XM_030252825.2 → XP_030108685.1  5'-3' DNA helicase ZGRF1 isoform X6

      Conserved Domains (3) summary
      TIGR00376
      Location:542 → 977
      TIGR00376; DNA helicase, putative
      pfam06839
      Location:241 → 285
      zf-GRF; GRF zinc finger
      pfam13087
      Location:748 → 955
      AAA_12; AAA domain

    7. XM_017319727.3 → XP_017175216.1  5'-3' DNA helicase ZGRF1 isoform X5

      Conserved Domains (3) summary
      TIGR00376
      Location:694 → 1129
      TIGR00376; DNA helicase, putative
      pfam06839
      Location:393 → 437
      zf-GRF; GRF zinc finger
      pfam13087
      Location:900 → 1107
      AAA_12; AAA domain

    8. XM_036163332.1 → XP_036019225.1  5'-3' DNA helicase ZGRF1 isoform X8

      Conserved Domains (3) summary
      pfam06839
      Location:9 → 53
      zf-GRF; GRF zinc finger
      pfam13087
      Location:516 → 700
      AAA_12; AAA domain
      cl28899
      Location:275 → 539
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    9. XM_036163331.1 → XP_036019224.1  5'-3' DNA helicase ZGRF1 isoform X7

      Conserved Domains (3) summary
      pfam06839
      Location:9 → 53
      zf-GRF; GRF zinc finger
      pfam13087
      Location:516 → 723
      AAA_12; AAA domain
      cl28899
      Location:275 → 525
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RNA

    1. XR_867232.3 RNA Sequence

      Related
      ENSMUST00000200490.5

    2. XR_004941395.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGT4.2 GenPept UniProtKB/Swiss-Prot:Q0VGT4

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