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    ADAM33 ADAM metallopeptidase domain 33 [ Homo sapiens (human) ]

    Gene ID: 80332, updated on 27-Nov-2024

    Summary

    Official Symbol
    ADAM33provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 33provided by HGNC
    Primary source
    HGNC:HGNC:15478
    See related
    Ensembl:ENSG00000149451 MIM:607114; AllianceGenome:HGNC:15478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf153; DJ964F7.1
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAM33 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3667975..3682010, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3698909..3712954, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3648622..3662657, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene attractin Neighboring gene splicing factor 3a, subunit 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3601641-3601840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12623 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:3647557-3648086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3651223-3651828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3657784-3658386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3658990-3659591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3662082-3662975 Neighboring gene GDNF family receptor alpha 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3678505-3679004 Neighboring gene Sharpr-MPRA regulatory region 3812 Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12624 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3713394-3713973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3722898-3723425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3725082-3725992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3729440-3729992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3729993-3730543 Neighboring gene heat shock protein family A (Hsp70) member 12B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35308, FLJ36751, MGC71889, MGC149823, DKFZp434K0521

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 33
    Names
    ADAM 33
    a disintegrin and metalloprotease 33
    a disintegrin and metalloproteinase domain 33
    disintegrin and reprolysin metalloproteinase family protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282447.3NP_001269376.1  disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor

      See identical proteins and their annotated locations for NP_001269376.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform gamma), compared to isoform alpha. The encoded isoform (gamma) may undergo proteolytic processing similar to isoform alpha.
      Source sequence(s)
      AF466287, AK126487, AL356755
      Consensus CDS
      CCDS63219.1
      UniProtKB/TrEMBL
      A2A2L3, Q08AM2
      Related
      ENSP00000369190.4, ENST00000379861.8
      Conserved Domains (5) summary
      smart00050
      Location:426500
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:502644
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:210407
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:210409
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83164
      Pep_M12B_propep; Reprolysin family propeptide
    2. NM_025220.5NP_079496.1  disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein

      See identical proteins and their annotated locations for NP_079496.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (alpha).
      Source sequence(s)
      AL356755, AY358314
      Consensus CDS
      CCDS13058.1
      UniProtKB/Swiss-Prot
      A0A1K6, Q5JT75, Q5JT76, Q8N0W6, Q9BZ11
      UniProtKB/TrEMBL
      Q08AM2
      Related
      ENSP00000348912.3, ENST00000356518.7
      Conserved Domains (5) summary
      smart00050
      Location:426500
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:502644
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:210407
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:210409
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83164
      Pep_M12B_propep; Reprolysin family propeptide
    3. NM_153202.4NP_694882.1  disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

      See identical proteins and their annotated locations for NP_694882.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. It encodes isoform beta, which lacks an internal segment, but has the same N- and C-termini as isoform alpha. The encoded isoform (beta) may undergo proteolytic processing similar to isoform alpha.
      Source sequence(s)
      AK126487, AL356755, DB225158
      UniProtKB/TrEMBL
      Q08AM2
      Related
      ENSP00000322550.5, ENST00000350009.6
      Conserved Domains (5) summary
      smart00050
      Location:426500
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:502643
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:210407
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:210409
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83164
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3667975..3682010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529367.2XP_011527669.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X5

      UniProtKB/TrEMBL
      Q08AM2
      Conserved Domains (5) summary
      smart00050
      Location:425499
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:501643
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:209406
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:209408
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:88163
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_011529366.2XP_011527668.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

      UniProtKB/TrEMBL
      Q08AM2
      Conserved Domains (5) summary
      smart00050
      Location:438512
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:514656
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:222419
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:222421
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:88176
      Pep_M12B_propep; Reprolysin family propeptide
    3. XM_006723640.2XP_006723703.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

      UniProtKB/TrEMBL
      Q08AM2
      Conserved Domains (5) summary
      smart00050
      Location:436510
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:512654
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:223417
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:223419
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83177
      Pep_M12B_propep; Reprolysin family propeptide
    4. XM_047440516.1XP_047296472.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X7

    5. XM_047440515.1XP_047296471.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X6

    6. XM_047440514.1XP_047296470.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    7. XM_005260843.2XP_005260900.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

      UniProtKB/TrEMBL
      Q08AM2
      Conserved Domains (5) summary
      smart00050
      Location:439513
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:515657
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:223420
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:223422
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83177
      Pep_M12B_propep; Reprolysin family propeptide
    8. XM_011529370.2XP_011527672.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

      See identical proteins and their annotated locations for XP_011527672.1

      Conserved Domains (5) summary
      smart00050
      Location:439513
      DISIN; Homologues of snake disintegrins
      cd04269
      Location:223420
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:223422
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83177
      Pep_M12B_propep; Reprolysin family propeptide
      cl15456
      Location:515548
      ADAM_CR; ADAM cysteine-rich
    9. XM_047440517.1XP_047296473.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

    10. XM_017028081.3XP_016883570.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X11

    11. XM_011529371.3XP_011527673.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X9

      Conserved Domains (2) summary
      cd04269
      Location:223343
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01562
      Location:83177
      Pep_M12B_propep; Reprolysin family propeptide
    12. XM_017028080.3XP_016883569.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X10

    13. XM_006723644.3XP_006723707.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X12

      Conserved Domains (4) summary
      smart00050
      Location:439479
      DISIN; Homologues of snake disintegrins
      cd04269
      Location:223420
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:223422
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:83177
      Pep_M12B_propep; Reprolysin family propeptide
    14. XM_017028083.2XP_016883572.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X14

      UniProtKB/TrEMBL
      B4E1Y6
    15. XM_017028082.2XP_016883571.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X13

    RNA

    1. XR_937152.2 RNA Sequence

    2. XR_937151.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3698909..3712954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324050.1XP_054180025.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X5

    2. XM_054324048.1XP_054180023.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

    3. XM_054324049.1XP_054180024.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

    4. XM_054324052.1XP_054180027.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X7

    5. XM_054324051.1XP_054180026.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X6

    6. XM_054324047.1XP_054180022.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

    7. XM_054324046.1XP_054180021.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

    8. XM_054324054.1XP_054180029.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

    9. XM_054324053.1XP_054180028.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

    10. XM_054324057.1XP_054180032.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X11

    11. XM_054324055.1XP_054180030.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X9

    12. XM_054324056.1XP_054180031.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X10

    13. XM_054324058.1XP_054180033.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X12

    14. XM_054324060.1XP_054180035.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X14

    15. XM_054324059.1XP_054180034.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X13

    RNA

    1. XR_008485300.1 RNA Sequence

    2. XR_008485299.1 RNA Sequence