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    CT45A2 cancer/testis antigen family 45 member A2 [ Homo sapiens (human) ]

    Gene ID: 728911, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CT45A2provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A2provided by HGNC
    Primary source
    HGNC:HGNC:28400
    See related
    Ensembl:ENSG00000271449 MIM:300793; AllianceGenome:HGNC:28400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT45-2; CT45.2; CT45A8; CT45A9
    Summary
    This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. [provided by RefSeq, Apr 2014]
    Expression
    Restricted expression toward testis (RPKM 8.0) See more
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    Genomic context

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    See CT45A2 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135811668..135820066, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134120072..134128473, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_004070887.1 (742811..751155, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A5 Neighboring gene cancer/testis antigen family 45 member A6 Neighboring gene cancer/testis antigen family 45 member A7 Neighboring gene cancer/testis antigen family 45 member A8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations. Yang K, et al. Br J Pharmacol, 2019 Dec. PMID 31322286, Free PMC Article
    2. A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. Cerveira N, et al. BMC Cancer, 2010 Sep 29. PMID 20920256, Free PMC Article
    3. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
    4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    5. The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis. Vaughan N, et al. Sci Rep, 2022 Aug 1. PMID 35915203, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations.
      Title: Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations.
    2. CT45A2 is a novel spliced MLL fusion partner in de novo biphenotypic acute leukemia [case report]
      Title: A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    cancer/testis antigen family 45 member A2
    Names
    Cancer/testis antigen 45A8
    Cancer/testis antigen 45A9
    Cancer/testis antigen family 45 member A8
    Cancer/testis antigen family 45 member A9
    cancer/testis antigen 45-2
    cancer/testis antigen 45A2
    cancer/testis antigen CT45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021269.2 RefSeqGene

      Range
      5001..13345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_152582.7 → NP_689795.4  cancer/testis antigen family 45 member A2

      See identical proteins and their annotated locations for NP_689795.4

      Status: REVIEWED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76031.1
      UniProtKB/Swiss-Prot
      P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
      Related
      ENSP00000483619.1, ENST00000612907.2
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135811668..135820066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531389.3 → XP_011529691.1  cancer/testis antigen family 45 member A2 isoform X1

      See identical proteins and their annotated locations for XP_011529691.1

      UniProtKB/Swiss-Prot
      P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. XM_006724783.3 → XP_006724846.1  cancer/testis antigen family 45 member A2 isoform X1

      See identical proteins and their annotated locations for XP_006724846.1

      UniProtKB/Swiss-Prot
      P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
      Related
      ENSP00000474632.2, ENST00000605791.7
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134120072..134128473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327685.1 → XP_054183660.1  cancer/testis antigen family 45 member A2 isoform X1

    2. XM_054327686.1 → XP_054183661.1  cancer/testis antigen family 45 member A2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DJT8.3 GenPept UniProtKB/Swiss-Prot:Q5DJT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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