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    TRIM74 tripartite motif containing 74 [ Homo sapiens (human) ]

    Gene ID: 378108, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TRIM74provided by HGNC
    Official Full Name
    tripartite motif containing 74provided by HGNC
    Primary source
    HGNC:HGNC:17453
    See related
    Ensembl:ENSG00000155428 MIM:612550; AllianceGenome:HGNC:17453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIM50C
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in testis (RPKM 13.0), bone marrow (RPKM 5.7) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TRIM74 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (72954868..72969681, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (74183097..74197887, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (72430016..72439997, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:72339695-72339882 Neighboring gene speedy/RINGO cell cycle regulator family member E7, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:72349748-72350248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26120 Neighboring gene POM121 transmembrane nucleoporin Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:72395219-72395780 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:72395781-72396341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:72396775-72397974 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:72404605-72404795 Neighboring gene uncharacterized LOC124901671 Neighboring gene NSUN5 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:72431501-72432053 Neighboring gene FKBP6 pseudogene 1 Neighboring gene uncharacterized LOC124901672 Neighboring gene STAG3 cohesin complex component like 3 (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution. Kim YJ, et al. Gene, 2015 Dec 1. PMID 26196062
    2. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. Micale L, et al. Eur J Hum Genet, 2008 Sep. PMID 18398435, Free PMC Article
    3. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Arking DE, et al. Nat Genet, 2014 Aug. PMID 24952745, Free PMC Article
    4. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. Hayes SD, et al. J Biol Chem, 2012 Dec 14. PMID 23105109, Free PMC Article
    5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. Woodsmith J, et al. Mol Cell Proteomics, 2012 Jul. PMID 22493164, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maps within the critical region of Williams-Beuren syndrome.
      Title: Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45440

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 74
    Names
    tripartite motif-containing 50C
    tripartite motif-containing protein 50C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317815.2 → NP_001304744.1  tripartite motif-containing protein 74

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF498999, BC033871
      Consensus CDS
      CCDS5545.1
      UniProtKB/Swiss-Prot
      B7WP46, Q86UV6
      UniProtKB/TrEMBL
      I3L0H3
      Conserved Domains (2) summary
      cd00021
      Location:90 → 125
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_198853.3 → NP_942150.1  tripartite motif-containing protein 74

      See identical proteins and their annotated locations for NP_942150.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF498999, BC033871
      Consensus CDS
      CCDS5545.1
      UniProtKB/Swiss-Prot
      B7WP46, Q86UV6
      UniProtKB/TrEMBL
      I3L0H3
      Related
      ENSP00000285805.3, ENST00000285805.3
      Conserved Domains (2) summary
      cd00021
      Location:90 → 125
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      72954868..72969681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420354.1 → XP_047276310.1  tripartite motif-containing protein 74 isoform X3

    2. XM_011516190.3 → XP_011514492.1  tripartite motif-containing protein 74 isoform X2

      See identical proteins and their annotated locations for XP_011514492.1

      UniProtKB/TrEMBL
      J3KQW6
      Conserved Domains (1) summary
      cd00021
      Location:36 → 71
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    3. XM_047420352.1 → XP_047276308.1  tripartite motif-containing protein 74 isoform X2

    4. XM_047420355.1 → XP_047276311.1  tripartite motif-containing protein 74 isoform X3

    5. XM_047420353.1 → XP_047276309.1  tripartite motif-containing protein 74 isoform X2

    6. XM_011516187.4 → XP_011514489.1  tripartite motif-containing protein 74 isoform X4

      See identical proteins and their annotated locations for XP_011514489.1

      UniProtKB/Swiss-Prot
      B7WP46, Q86UV6
      UniProtKB/TrEMBL
      I3L0H3
      Conserved Domains (2) summary
      cd00021
      Location:90 → 125
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    7. XM_047420356.1 → XP_047276312.1  tripartite motif-containing protein 74 isoform X5

    8. XM_047420350.1 → XP_047276306.1  tripartite motif-containing protein 74 isoform X1

    9. XM_011516189.3 → XP_011514491.1  tripartite motif-containing protein 74 isoform X1

      See identical proteins and their annotated locations for XP_011514491.1

      UniProtKB/TrEMBL
      I3L0H3
      Related
      ENSP00000378665.1, ENST00000395244.5
      Conserved Domains (2) summary
      cd00021
      Location:90 → 125
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      74183097..74197887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358175.1 → XP_054214150.1  tripartite motif-containing protein 74 isoform X6

    2. XM_054358178.1 → XP_054214153.1  tripartite motif-containing protein 74 isoform X2

    3. XM_054358177.1 → XP_054214152.1  tripartite motif-containing protein 74 isoform X2

    4. XM_054358173.1 → XP_054214148.1  tripartite motif-containing protein 74 isoform X6

    5. XM_054358181.1 → XP_054214156.1  tripartite motif-containing protein 74 isoform X3

    6. XM_054358179.1 → XP_054214154.1  tripartite motif-containing protein 74 isoform X2

    7. XM_054358174.1 → XP_054214149.1  tripartite motif-containing protein 74 isoform X6

    8. XM_054358176.1 → XP_054214151.1  tripartite motif-containing protein 74 isoform X1

    9. XM_054358180.1 → XP_054214155.1  tripartite motif-containing protein 74 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UV6.1 GenPept UniProtKB/Swiss-Prot:Q86UV6

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