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    OR7C1 olfactory receptor family 7 subfamily C member 1 [ Homo sapiens (human) ]

    Gene ID: 26664, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OR7C1provided by HGNC
    Official Full Name
    olfactory receptor family 7 subfamily C member 1provided by HGNC
    Primary source
    HGNC:HGNC:8373
    See related
    Ensembl:ENSG00000127530 AllianceGenome:HGNC:8373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR7C4; OR19-5; TPCR86; HSTPCR86P; CIT-HSP-146E8
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See OR7C1 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14798515..14835185, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14926070..14962748, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14909327..14945997, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily A member 5 Neighboring gene olfactory receptor family 7 subfamily A member 10 Neighboring gene olfactory receptor family 7 subfamily A member 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. Vanderhaeghen P, et al. Biochem Biophys Res Commun, 1997 Aug 18. PMID 9268701
    2. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. Vanderhaeghen P, et al. Genomics, 1997 Feb 1. PMID 9119360
    3. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    4. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 7C1
    Names
    olfactory receptor 7C4
    olfactory receptor OR19-16
    olfactory receptor TPCR86
    olfactory receptor, family 7, subfamily C, member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370485.4 → NP_001357414.2  olfactory receptor 7C1

      Status: VALIDATED

      Source sequence(s)
      AC005255
      Consensus CDS
      CCDS12317.1
      UniProtKB/Swiss-Prot
      O76099, Q15621, Q6IFP2, Q96R94
      UniProtKB/TrEMBL
      A0A126GWS1, A0A126GWU6
      Related
      ENSP00000493429.1, ENST00000641666.2
      Conserved Domains (1) summary
      cd15234
      Location:26 → 301
      7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_198944.1 → NP_945182.1  olfactory receptor 7C1

      See identical proteins and their annotated locations for NP_945182.1

      Status: VALIDATED

      Source sequence(s)
      AC005255
      Consensus CDS
      CCDS12317.1
      UniProtKB/Swiss-Prot
      O76099, Q15621, Q6IFP2, Q96R94
      UniProtKB/TrEMBL
      A0A126GWS1, A0A126GWU6
      Related
      ENSP00000248073.2, ENST00000248073.2
      Conserved Domains (1) summary
      cd15234
      Location:26 → 301
      7tmA_OR7-like; olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      14798515..14835185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      14926070..14962748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76099.1 GenPept UniProtKB/Swiss-Prot:O76099

    Gene LinkOut

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