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    TP53TG3 TP53 target 3 [ Homo sapiens (human) ]

    Gene ID: 24150, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TP53TG3provided by HGNC
    Official Full Name
    TP53 target 3provided by HGNC
    Primary source
    HGNC:HGNC:30759
    See related
    Ensembl:ENSG00000183632 MIM:617482; AllianceGenome:HGNC:30759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P53TG3; TP53TG3A; TP53TG3E; TP53TG3F
    Summary
    Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 7.8), adrenal (RPKM 0.7) and 2 other tissues See more
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    Genomic context

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    See TP53TG3 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (32673530..32676165, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (33087984..33090621, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (32684851..32687486, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 153 member D, pseudogene Neighboring gene uncharacterized LOC107984013 Neighboring gene uncharacterized LOC105371177 Neighboring gene ABHD17A pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. 16p11.2-p12.2 duplication syndrome; a genomic condition differentiated from euchromatic variation of 16p11.2. Barber JC, et al. Eur J Hum Genet, 2013 Feb. PMID 22828807, Free PMC Article
    2. Identification of epistatic effects using a protein-protein interaction database. Sun YV, et al. Hum Mol Genet, 2010 Nov 15. PMID 20736252, Free PMC Article
    3. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. Ng CC, et al. Genes Chromosomes Cancer, 1999 Dec. PMID 10534768
    4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TP53-target gene 3 protein
    Names
    TP53-inducible gene 3 protein
    p53 target gene 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016212.5 → NP_057296.1  TP53-target gene 3 protein

      See identical proteins and their annotated locations for NP_057296.1

      Status: VALIDATED

      Source sequence(s)
      AC138907
      Consensus CDS
      CCDS45475.1
      UniProtKB/Swiss-Prot
      B2R5K6, Q4KN31, Q9ULY9, Q9ULZ0
      Related
      ENSP00000381672.4, ENST00000398682.5

    RNA

    1. NR_110886.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138907

    2. NR_110910.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138907

    3. NR_158180.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138907

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      32673530..32676165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545779.2 → XP_011544081.1  TP53-target gene 3 protein isoform X1

      See identical proteins and their annotated locations for XP_011544081.1

      UniProtKB/Swiss-Prot
      Q9ULZ0
      Related
      ENSP00000455448.1, ENST00000565622.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      33087984..33090621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379988.1 → XP_054235963.1  TP53-target gene 3 protein isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001267813.1: Suppressed sequence

      Description
      NM_001267813.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_015369.1: Suppressed sequence

      Description
      NM_015369.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULZ0.2 GenPept UniProtKB/Swiss-Prot:Q9ULZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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