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    Dmrtc1a DMRT-like family C1a [ Mus musculus (house mouse) ]

    Gene ID: 70887, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dmrtc1aprovided by MGI
    Official Full Name
    DMRT-like family C1aprovided by MGI
    Primary source
    MGI:MGI:1918137
    See related
    Ensembl:ENSMUSG00000031323 AllianceGenome:MGI:1918137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DMRTC1; Dmrt8.1; 1700030H14Rik; 4921520P21Rik
    Summary
    Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spinal cord. Orthologous to several human genes including DMRTC1 (DMRT like family C1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 10.0), genital fat pad adult (RPKM 7.3) and 7 other tissues See more
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    Genomic context

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    See Dmrtc1a in Genome Data Viewer
    Location:
    X D; X 45.79 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101946822..101953753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102903216..102910145, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700031F05 gene Neighboring gene STARR-seq mESC enhancer starr_47679 Neighboring gene predicted pseudogene 9133 Neighboring gene family with sequence similarity 236, member E Neighboring gene family with sequence similarity 236, member C Neighboring gene predicted gene 5126

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse. Veith AM, et al. Genomics, 2006 Aug. PMID 16488114
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization.
      Title: Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    doublesex- and mab-3-related transcription factor C1
    Names
    doublesex and mab-3 related transcription factor 8.1
    likely ortologue to human doublesex-and mab-3-related transcription factor C1 (Dmrtc1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038616.2 → NP_001033705.2  doublesex- and mab-3-related transcription factor C1 isoform c

      See identical proteins and their annotated locations for NP_001033705.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons and an internal segment in the 3' region, but has an alternate 5' sequence, as compared to variant 1. The resulting isoform (c) is shorter and has different N- and C-termini, as compared to isoform a.
      Source sequence(s)
      AK006548, AL773565, BB310814, BC147175, DQ316774
      Consensus CDS
      CCDS53161.1
      UniProtKB/Swiss-Prot
      B1AX31, B1AX32, Q2PMY0, Q9D5U3, Q9D9R7
      Related
      ENSMUSP00000113569.2, ENSMUST00000121197.8
      Conserved Domains (1) summary
      pfam15791
      Location:68 → 180
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    2. NM_027591.3 → NP_081867.1  doublesex- and mab-3-related transcription factor C1 isoform a

      See identical proteins and their annotated locations for NP_081867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK014934, AL773565
      Consensus CDS
      CCDS30327.1
      UniProtKB/TrEMBL
      B1AX33, B1AX34
      Related
      ENSMUSP00000033686.2, ENSMUST00000033686.2
      Conserved Domains (1) summary
      pfam15791
      Location:113 → 190
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    3. NM_029378.2 → NP_083654.1  doublesex- and mab-3-related transcription factor C1 isoform b

      See identical proteins and their annotated locations for NP_083654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons but has an alternate 5' sequence, as compared to variant 1. The resulting isoform (b) is shorter and has a different N-terminus, as compared to isoform a.
      Source sequence(s)
      BB310814, DQ316773
      Consensus CDS
      CCDS53162.1
      UniProtKB/Swiss-Prot
      Q9D9R7
      Related
      ENSMUSP00000112572.2, ENSMUST00000120808.8
      Conserved Domains (1) summary
      pfam15791
      Location:68 → 145
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      101946822..101953753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318619.3 → XP_017174108.1  doublesex- and mab-3-related transcription factor C1 isoform X2

      UniProtKB/TrEMBL
      B1AX33
      Conserved Domains (1) summary
      pfam15791
      Location:73 → 187
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    2. XM_006528280.5 → XP_006528343.1  doublesex- and mab-3-related transcription factor C1 isoform X1

      UniProtKB/TrEMBL
      B1AX33
      Related
      ENSMUSP00000112458.2, ENSMUST00000119624.8
      Conserved Domains (1) summary
      pfam15791
      Location:112 → 226
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9R7.2 GenPept UniProtKB/Swiss-Prot:Q9D9R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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