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    Dcdc2b doublecortin domain containing 2b [ Mus musculus (house mouse) ]

    Gene ID: 100504491, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dcdc2bprovided by MGI
    Official Full Name
    doublecortin domain containing 2bprovided by MGI
    Primary source
    MGI:MGI:2686212
    See related
    Ensembl:ENSMUSG00000078552 AllianceGenome:MGI:2686212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1366; Gm12964
    Summary
    This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), lung adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcdc2b in Genome Data Viewer
    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129501723..129508270, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129607930..129614483, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 167, member B Neighboring gene STARR-positive B cell enhancer ABC_E11717 Neighboring gene eukaryotic translation initiation factor 3, subunit I Neighboring gene transmembrane protein 234 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129287304-129287568 Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene IQ motif containing C Neighboring gene coiled coil domain containing 28B Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene predicted gene, 34305

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Common and divergent roles for members of the mouse DCX superfamily. Coquelle FM, et al. Cell Cycle, 2006 May. PMID 16628014
    2. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041
    3. The evolving doublecortin (DCX) superfamily. Reiner O, et al. BMC Genomics, 2006 Jul 26. PMID 16869982, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    doublecortin domain-containing protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195730.2 → NP_001182659.1  doublecortin domain-containing protein 2B

      Status: VALIDATED

      Source sequence(s)
      AL671759
      Consensus CDS
      CCDS57299.1
      UniProtKB/TrEMBL
      F7BCK0, J3KML0
      Related
      ENSMUSP00000135913.2, ENSMUST00000179209.8
      Conserved Domains (2) summary
      cd01617
      Location:4 → 82
      DCX; Ubiquitin-like domain of DCX
      cl00155
      Location:91 → 177
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129501723..129508270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502634.5 → XP_006502697.1  doublecortin domain-containing protein 2B isoform X4

      Conserved Domains (1) summary
      cl28922
      Location:4 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006502633.5 → XP_006502696.1  doublecortin domain-containing protein 2B isoform X3

      UniProtKB/TrEMBL
      F7BCK0
      Conserved Domains (1) summary
      cl28922
      Location:4 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_006502631.5 → XP_006502694.1  doublecortin domain-containing protein 2B isoform X1

      UniProtKB/TrEMBL
      F7BCK0
      Related
      ENSMUSP00000101653.3, ENSMUST00000106037.3
      Conserved Domains (1) summary
      cl28922
      Location:123 → 201
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_006502632.5 → XP_006502695.1  doublecortin domain-containing protein 2B isoform X2

      UniProtKB/TrEMBL
      F7BCK0
      Conserved Domains (1) summary
      cl28922
      Location:123 → 201
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. XM_030253068.2 → XP_030108928.1  doublecortin domain-containing protein 2B isoform X5

      Conserved Domains (1) summary
      cl28922
      Location:1 → 39
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. XM_006502636.5 → XP_006502699.1  doublecortin domain-containing protein 2B isoform X6

      Conserved Domains (1) summary
      cl28922
      Location:4 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    7. XM_036163556.1 → XP_036019449.1  doublecortin domain-containing protein 2B isoform X6

      Conserved Domains (1) summary
      cl28922
      Location:4 → 82
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version

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