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    DUR3 Dur3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856370, updated on 1-Aug-2024

    Summary

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    Gene symbol
    DUR3
    Gene description
    Dur3p
    Primary source
    FungiDB:YHL016C
    Locus tag
    YHL016C
    See related
    SGD:S000001008; AllianceGenome:SGD:S000001008; VEuPathDB:YHL016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables putrescine transmembrane transporter activity; spermidine transmembrane transporter activity; and urea transmembrane transporter activity. Involved in putrescine transport; spermidine transport; and urea transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DUR3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (72037..74244, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene 4a-hydroxytetrahydrobiopterin dehydratase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutant Potential Ubiquitination Sites in Dur3p Enhance the Urea and Ethyl Carbamate Reduction in a Model Rice Wine System. Zhang P, et al. J Agric Food Chem, 2017 Mar 1. PMID 28185458
    2. Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae. ElBerry HM, et al. J Bacteriol, 1993 Aug. PMID 8335627, Free PMC Article
    3. Single-cell copy number variant detection reveals the dynamics and diversity of adaptation. Lauer S, et al. PLoS Biol, 2018 Dec. PMID 30562346, Free PMC Article
    4. Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae. Uemura T, et al. J Biol Chem, 2007 Mar 9. PMID 17218313
    5. A second nitrogen permease regulator in Saccharomyces cerevisiae. Rousselet G, et al. FEBS Lett, 1995 Feb 13. PMID 7867803

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mutation of Dur3p ubiquitination sites could significantly affect urea utilization and formation.
      Title: Mutant Potential Ubiquitination Sites in Dur3p Enhance the Urea and Ethyl Carbamate Reduction in a Model Rice Wine System.
    2. DUR3 and SAM3 are major polyamine uptake proteins in yeast.
      Title: Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae.
    3. These results suggest that, in addition to the efflux boron transporter BOR1, DUR3 and FPS1 play important roles in regulating the cellular boron concentration.
      Title: Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables putrescine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables putrescine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables putrescine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables spermidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spermidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables urea transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urea transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urea transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in putrescine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urea transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urea transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dur3p
    NP_011847.1
    • Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      72037..74244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179096.1 → NP_011847.1  TPA: Dur3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKP5, P33413
      UniProtKB/TrEMBL
      B3LSA2, C7GIS0, G2WF50, N1P9J3
      Conserved Domains (1) summary
      cd11476
      Location:14 → 517
      SLC5sbd_DUR3; Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33413.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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