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    [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851433, updated on 11-Sep-2024

    Summary

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    Primary source
    SGD:S000002282
    Locus tag
    YDL124W
    See related
    AllianceGenome:SGD:S000002282; FungiDB:YDL124W; VEuPathDB:YDL124W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alditol:NADP+ 1-oxidoreductase activity; alpha-keto amide reductase activity; and alpha-keto ester reductase activity. Involved in several processes, including cellular amide metabolic process; cellular ketone metabolic process; and cellular response to oxidative stress. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (240259..241197)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene AAA family ATPase CDC48 Neighboring gene adenosine 5'-monophosphoramidase Neighboring gene Sna4p Neighboring gene ubiquitin-specific protease UBP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using biocatalysis to integrate organic chemistry into a molecular biology laboratory course. Beers M, et al. Biochem Mol Biol Educ, 2012 Mar-Apr. PMID 22419594
    2. Purification and characterization of alpha-keto amide reductase from Saccharomyces cerevisiae. Ishihara K, et al. Biosci Biotechnol Biochem, 2004 Nov. PMID 15564669
    3. Enantiodivergent, biocatalytic routes to both taxol side chain antipodes. Feske BD, et al. J Org Chem, 2005 Nov 11. PMID 16268655
    4. Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxy butanoate using a Saccharomyces cerevisiae reductase: enantioselectivity and enzyme-substrate docking studies. Jung J, et al. Biochim Biophys Acta, 2010 Sep. PMID 20601218
    5. Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Chang Q, et al. Biochim Biophys Acta, 2008 Feb. PMID 17919749, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YNL134C and YDL124W were also identified as candidate Yap2 target genes.
      Title: Candidate target genes for the Saccharomyces cerevisiae transcription factor, Yap2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-keto amide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-keto ester reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular ketone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    aldo-keto reductase superfamily protein
    NP_010159.1
    • NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      240259..241197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180183.1 → NP_010159.1  TPA: aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRM6, Q07551
      UniProtKB/TrEMBL
      A6ZXK5, C8Z6H9, N1P5K1
      Conserved Domains (1) summary
      cd19120
      Location:13 → 291
      AKR_AKR3C2-3; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07551.1

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