ZIP1 Zip1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ZIP1
Gene description: Zip1p
Primary source: FungiDB:YDR285W
Locus tag: YDR285W
See related: SGD:S000002693; AllianceGenome:SGD:S000002693; VEuPathDB:YDR285W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables SUMO polymer binding activity. Involved in several processes, including meiosis I; negative regulation of reciprocal meiotic recombination; and positive regulation of protein sumoylation. Acts upstream of or within positive regulation of strand invasion. Located in chromosome, centromeric region and transverse filament. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ZIP1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1032436..1035063)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis.
Title: Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis.
deletion of Zip1 residues 15-20 does not detectably prevent Zip3's localization at Zip1 polycomplex and supports some MutSgamma crossing over but prevents normal SC assembly and Ecm11 SUMOylation.
Title: Crossover recombination and synapsis are linked by adjacent regions within the N terminus of the Zip1 synaptonemal complex protein.
From our results, we propose that the localization of Zip1 at the centromere may provide an additional constraining factor that promotes monopolin to cross-link the sister kinetochores enabling them to mono-orient.
Title: Evidence of Zip1 Promoting Sister Kinetochore Mono-orientation During Meiosis in Budding Yeast.
Centromere plasmid disjunction requires the N-terminus of Zip1.
Title: A ZIP1 separation-of-function allele reveals that centromere pairing drives meiotic segregation of achiasmate chromosomes in budding yeast.
proteolytic core and regulatory proteasome particles were recruited to chromosomes by Zip3, the ortholog of mammalian E3 ligase RNF212, and synaptonemal complex protein Zip1 .
Title: Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome.
The excess crossovers observed in synaptonemal complex (SC), central element-deficient mutants are Msh4, Zip1, and Zip4 dependent, clearly indicating the existence of two classes of SC proteins-a class with procrossover function(s) that are also necessary for SC assembly and a class that is not required for crossover formation but essential for SC assembly
Title: Synaptonemal Complex Proteins of Budding Yeast Define Reciprocal Roles in MutSγ-Mediated Crossover Formation.
We discuss a model in which central element proteins are core building blocks that stabilize the architecture of SC near Zip1's N termini
Title: SUMO localizes to the central element of synaptonemal complex and is required for the full synapsis of meiotic chromosomes in budding yeast.
Data demonstrate that chromosomes are preloaded with Zip1p in a manner that may promote synapsis.
Title: Meiotic cohesin promotes pairing of nonhomologous centromeres in early meiotic prophase.
Different functions of Zip1 display differential sensitivities to changes in expression levels.
Title: Separation of roles of Zip1 in meiosis revealed in heterozygous mutants of Saccharomyces cerevisiae.
zip1 promotes the segregation of nonexchange chromosomes that are not tethered byp zip1 at centromeres.
Title: The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SUMO polymer binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of strand invasion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to site of double-strand break	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed
located_in transverse filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Zip1p

NP_010571.1

Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1032436..1035063

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180593.1 → NP_010571.1 TPA: Zip1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010571.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSR5, P31111

UniProtKB/TrEMBL

A6ZYN4, B3LG09, C7GQT6, C8Z5J7, G2WB24, N1P555

Conserved Domains (2) summary

COG1196
Location:208 → 748

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:479 → 749

SMC_prok_B; chromosome segregation protein SMC, common bacterial type