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    PFU1 Pfu1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851900, updated on 17-May-2024

    Summary

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    Gene symbol
    PFU1
    Gene description
    Pfu1p
    Primary source
    FungiDB:YDR306C
    Locus tag
    YDR306C
    See related
    SGD:S000002714; AllianceGenome:SGD:S000002714; VEuPathDB:YDR306C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PFU1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1073735..1075171, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase family protein CPR5 Neighboring gene bis(5'-adenosyl)-triphosphatase Neighboring gene tRNA-Val Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Dubacq C, et al. Eukaryot Cell, 2002 Aug. PMID 12456005, Free PMC Article
    2. Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway. Rangarajan N, et al. J Biol Chem, 2019 Oct 4. PMID 31399514, Free PMC Article
    3. A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. Liu Y, et al. EMBO J, 2009 Nov 4. PMID 19763088, Free PMC Article
    4. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Willems AR, et al. Philos Trans R Soc Lond B Biol Sci, 1999 Sep 29. PMID 10582239, Free PMC Article
    5. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pfu1p
    NP_010592.1
    • F-box protein that regulates pheromone-dependent morphogenesis; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1073735..1075171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180614.1 → NP_010592.1  TPA: Pfu1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VST5, Q06640
      UniProtKB/TrEMBL
      A0A8H8UNK5, A6ZYQ4, B3LFZ0, B5VGI5, C7GQV6, C8Z5L7
      Conserved Domains (1) summary
      pfam13306
      Location:275 → 379
      LRR_5; Leucine rich repeats (6 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06640.1

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