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    RAD34 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851909, updated on 11-Sep-2024

    Summary

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    Official Symbol
    RAD34
    Primary source
    SGD:S000002722
    Locus tag
    YDR314C
    See related
    AllianceGenome:SGD:S000002722; FungiDB:YDR314C; VEuPathDB:YDR314C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in nucleotide-excision repair. Located in nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1090433..1092511, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein Neighboring gene phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase Neighboring gene inositol pentakisphosphate 2-kinase Neighboring gene putative RNA methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae. den Dulk B, et al. Mol Microbiol, 2005 Jun. PMID 15916602
    2. Complementary roles of yeast Rad4p and Rad34p in nucleotide excision repair of active and inactive rRNA gene chromatin. Tremblay M, et al. Mol Cell Biol, 2008 Dec. PMID 18936173, Free PMC Article
    3. RNA Polymerase-I-Dependent Transcription-coupled Nucleotide Excision Repair of UV-Induced DNA Lesions at Transcription Termination Sites, in Saccharomyces cerevisiae. Peyresaubes F, et al. Photochem Photobiol, 2017 Jan. PMID 27935059
    4. Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER. Lafrance-Vanasse J, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23295669, Free PMC Article
    5. A role for SUMO in nucleotide excision repair. Silver HR, et al. DNA Repair (Amst), 2011 Dec 10. PMID 21968059, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of XPC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-excision repair factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rad34p
    NP_010600.1
    • Protein involved in nucleotide excision repair (NER); homologous to RAD4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1090433..1092511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180622.1 → NP_010600.1  TPA: Rad34p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSU3, Q06665
      UniProtKB/TrEMBL
      A6ZYR2, B3LFY2, B5VGJ3, N1P752
      Conserved Domains (1) summary
      COG5535
      Location:2 → 682
      RAD4; DNA repair protein RAD4 [DNA replication, recombination, and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06665.1

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