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    ADE8 phosphoribosylglycinamide formyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852017, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ADE8
    Gene description
    phosphoribosylglycinamide formyltransferase
    Primary source
    FungiDB:YDR408C
    Locus tag
    YDR408C
    See related
    SGD:S000002816; AllianceGenome:SGD:S000002816; VEuPathDB:YDR408C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoribosylglycinamide formyltransferase activity. Involved in 'de novo' IMP biosynthetic process and adenine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADE8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1288215..1288859, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette multidrug transporter PDR15 Neighboring gene Trs120p Neighboring gene SUMO ligase SIZ1 Neighboring gene protein-S-isoprenylcysteine carboxyl O-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The accumulation of glycinamide ribotide by ade3 and ade8 mutants of Saccharomyces cerevisiae. Woods RA, et al. Biochem Biophys Res Commun, 1973 Aug 6. PMID 4581491
    2. Gene conversion, unequal crossing-over and mispairing at a non-tandem duplication during meiosis of Saccharomyces cerevisiae. Maloney DH, et al. Curr Genet, 1987. PMID 3329573
    3. A DNA sequence conferring high postmeiotic segregation frequency to heterozygous deletions in Saccharomyces cerevisiae is related to sequences associated with eucaryotic recombination hotspots. White JH, et al. Mol Cell Biol, 1988 Mar. PMID 3285179, Free PMC Article
    4. Sequence of a Drosophila DNA segment that functions in Saccharomyces cerevisiae and its regulation by a yeast promoter. Henikoff S, et al. Nucleic Acids Res, 1983 Feb 11. PMID 6300768, Free PMC Article
    5. The Saccharomyces cerevisiae ADE5,7 protein is homologous to overlapping Drosophila melanogaster Gart polypeptides. Henikoff S. J Mol Biol, 1986 Aug 20. PMID 3097325

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylglycinamide formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylglycinamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylglycinamide formyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphoribosylglycinamide formyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    phosphoribosylglycinamide formyltransferase
    NP_010696.3
    • Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1288215..1288859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180716.3 → NP_010696.3  TPA: phosphoribosylglycinamide formyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010696.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT40, P04161
      UniProtKB/TrEMBL
      A0A8H8UNV2, A6ZZ07, B3LFP6, B5VGU0, C7GSB6, C8Z5X2, G2WBE6, N1P761
      Conserved Domains (1) summary
      pfam00551
      Location:2 → 205
      Formyl_trans_N; Formyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04161.1

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