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    FMP32 Fmp32p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850498, updated on 9-Jun-2024

    Summary

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    Gene symbol
    FMP32
    Gene description
    Fmp32p
    Primary source
    FungiDB:YFL046W
    Locus tag
    YFL046W
    See related
    SGD:S000001848; AllianceGenome:SGD:S000001848; VEuPathDB:YFL046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PUT6
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly and regulation of proline metabolic process. Located in mitochondrial inner membrane. Orthologous to several human genes including CCDC90B (coiled-coil domain containing 90B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FMP32 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (42815..43438)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Emp47p Neighboring gene GTPase-activating protein RGD2 Neighboring gene phosphomannomutase SEC53 Neighboring gene ubiquitin-specific protease OTU1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of coiled-coil domains of MCU in mitochondrial calcium uptake. Yamamoto T, et al. Biochim Biophys Acta Bioenerg, 2019 Dec 1. PMID 31394096
    2. CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter. Paupe V, et al. Cell Metab, 2015 Jan 6. PMID 25565209
    3. Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Zulkifli M, et al. Nat Commun, 2020 Sep 25. PMID 32978391, Free PMC Article
    4. A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly. Schaper S, et al. Curr Biol, 2001 Nov 27. PMID 11728313
    5. Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. Beilharz T, et al. J Biol Chem, 2003 Mar 7. PMID 12514182

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proline metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fmp32p
    NP_116608.1
    • Regulator of mitochondrial proline metabolism; tethered with Put7p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      42815..43438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179921.1 → NP_116608.1  TPA: Fmp32p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTI4, P43557
      UniProtKB/TrEMBL
      A0A6A5Q1I0, A7A1Z3, B3LUG5, B5VHY1, C7GY68, C8Z7N6, G2WD95, N1P6K3
      Conserved Domains (1) summary
      pfam07798
      Location:32 → 205
      DUF1640; Protein of unknown function (DUF1640)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43557.1

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