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    NAT2 Nat2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853050, updated on 1-Aug-2024

    Summary

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    Gene symbol
    NAT2
    Gene description
    Nat2p
    Primary source
    FungiDB:YGR147C
    Locus tag
    YGR147C
    See related
    SGD:S000003379; AllianceGenome:SGD:S000003379; VEuPathDB:YGR147C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable acyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NAT2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (786054..786920, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ecl1p Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L24B Neighboring gene glycerophosphocholine acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A N(alpha)-acetyltransferase selectively transfers an acetyl group to NH2-terminal methionine residues: purification and partial characterization. Lee FJ, et al. Biochim Biophys Acta, 1997 Apr 4. PMID 9128142
    2. NAT2, an essential gene encoding methionine N alpha-acetyltransferase in the yeast Saccharomyces cerevisiae. Kulkarni MS, et al. J Biol Chem, 1994 May 6. PMID 8175741
    3. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article
    4. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643
    5. Mapping pathways and phenotypes by systematic gene overexpression. Sopko R, et al. Mol Cell, 2006 Feb 3. PMID 16455487

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nat2p
    NP_011663.3
    • hypothetical protein; has an apparent role in acetylation of N-terminal methionine residues

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      786054..786920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181276.3 → NP_011663.3  TPA: Nat2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011663.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUS8, P37293
      UniProtKB/TrEMBL
      G2WEM8, N1P9X1
      Conserved Domains (1) summary
      pfam06916
      Location:93 → 221
      DUF1279; Protein of unknown function (DUF1279)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37293.2

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