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    CCM1 Ccm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853053, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CCM1
    Gene description
    Ccm1p
    Primary source
    FungiDB:YGR150C
    Locus tag
    YGR150C
    See related
    SGD:S000003382; AllianceGenome:SGD:S000003382; VEuPathDB:YGR150C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DMR1; RRG2
    Summary
    Enables rRNA binding activity. Involved in RNA metabolic process; mitochondrial genome maintenance; and positive regulation of rRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CCM1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (790459..793053, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L24B Neighboring gene glycerophosphocholine acyltransferase Neighboring gene tRNA-Ala Neighboring gene Ras family GTPase RSR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast pentatricopeptide protein Dmr1 (Ccm1) binds a repetitive AU-rich motif in the small subunit mitochondrial ribosomal RNA. Piątkowski J, et al. RNA, 2020 Sep. PMID 32467310, Free PMC Article
    2. Mitochondrial-nuclear co-evolution leads to hybrid incompatibility through pentatricopeptide repeat proteins. Jhuang HY, et al. EMBO Rep, 2017 Jan. PMID 27920033, Free PMC Article
    3. Revisiting the yeast PPR proteins--application of an Iterative Hidden Markov Model algorithm reveals new members of the rapidly evolving family. Lipinski KA, et al. Mol Biol Evol, 2011 Oct. PMID 21546354
    4. DMR1 (CCM1/YGR150C) of Saccharomyces cerevisiae encodes an RNA-binding protein from the pentatricopeptide repeat family required for the maintenance of the mitochondrial 15S ribosomal RNA. Puchta O, et al. Genetics, 2010 Apr. PMID 20124025, Free PMC Article
    5. Ccm1p is a 15S rRNA primary transcript processing factor as elucidated by a novel in vivo system in Saccharomyces cerevisiae. Moreno JI, et al. Curr Genet, 2020 Aug. PMID 32152734, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ccm1p is a 15S rRNA primary transcript processing factor as elucidated by a novel in vivo system in Saccharomyces cerevisiae.
      Title: Ccm1p is a 15S rRNA primary transcript processing factor as elucidated by a novel in vivo system in Saccharomyces cerevisiae.
    2. The three lysine residues of Ccm1p pentatricopeptide repeat 2 are required for full bI4 maturase activity but not to maintain 15S rRNA levels.
      Title: Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ccm1p
    NP_011666.1
    • Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      790459..793053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181279.1 → NP_011666.1  TPA: Ccm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LI79, D6VUT1, P48237
      UniProtKB/TrEMBL
      A0A8H4FBQ6, N1P3T0
      Conserved Domains (3) summary
      PLN03218
      Location:297 → 395
      PLN03218; maturation of RBCL 1; Provisional
      sd00004
      Location:324 → 349
      PPR; PPR repeat [structural motif]
      pfam13041
      Location:355 → 398
      PPR_2; PPR repeat family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48237.1

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