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    TED1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854772, updated on 11-Sep-2024

    Summary

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    Official Symbol
    TED1
    Primary source
    SGD:S000001301
    Locus tag
    YIL039W
    See related
    AllianceGenome:SGD:S000001301; FungiDB:YIL039W; VEuPathDB:YIL039W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydrolase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (278426..279847)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Gvp36p Neighboring gene Apq12p Neighboring gene CCR4-NOT core subunit NOT3 Neighboring gene pheromone-regulated protein PRM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COPII coat composition is actively regulated by luminal cargo maturation. Manzano-Lopez J, et al. Curr Biol, 2015 Jan 19. PMID 25557665
    2. PMT1 deficiency extends the shortened replicative lifespan of TED1-deficient yeast in a Hac1p-dependent manner. Cui HJ, et al. FEMS Microbiol Lett, 2018 Nov 1. PMID 30265296
    3. Lipid moiety of glycosylphosphatidylinositol-anchored proteins contributes to the determination of their final destination in yeast. Yoko-O T, et al. Genes Cells, 2018 Oct. PMID 30133879
    4. Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Dilda PJ, et al. J Natl Cancer Inst, 2005 Oct 19. PMID 16234568
    5. Identification of yeast proteins necessary for cell-surface function of a potassium channel. Haass FA, et al. Proc Natl Acad Sci U S A, 2007 Nov 13. PMID 17989219, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ted1p
    NP_012225.1
    • GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan remodelase PGAP5; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      278426..279847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179389.1 → NP_012225.1  TPA: Ted1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVP3, P40533
      UniProtKB/TrEMBL
      A6ZVN0, B3LTP5, B5VKQ7, C7GVW7, C8ZAK7, G2WGA7, N1P266
      Conserved Domains (1) summary
      cd08164
      Location:83 → 421
      MPP_Ted1; Saccharomyces cerevisiae Ted1 and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40533.1

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