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    AIM21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854819, updated on 11-Sep-2024

    Summary

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    Official Symbol
    AIM21
    Primary source
    SGD:S000001442
    Locus tag
    YIR003W
    See related
    AllianceGenome:SGD:S000001442; FungiDB:YIR003W; VEuPathDB:YIR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to actin filament binding activity. Involved in mitochondrion migration along actin filament and negative regulation of actin filament polymerization. Located in actin cortical patch. Part of Aim21-Tda2 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (360885..362924)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Sgn1p Neighboring gene 3'-5' DNA helicase Neighboring gene Djp1p Neighboring gene U2 snRNP complex subunit IST3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis. Lamb AK, et al. Mol Biol Cell, 2021 Aug 1. PMID 34081539, Free PMC Article
    2. Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis. Farrell KB, et al. J Cell Biol, 2017 Aug 7. PMID 28706108, Free PMC Article
    3. A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast. Serpionov GV, et al. Sci Rep, 2015 Dec 17. PMID 26673834, Free PMC Article
    4. Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. Fazi B, et al. J Biol Chem, 2002 Feb 15. PMID 11668184
    5. Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables. Shin M, et al. Mol Biol Cell, 2018 Apr 15. PMID 29467252, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis.
      Title: Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis.
    2. The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
      Title: The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
    3. Loss of the cortical patch protein Aim21 suppresses the growth defect of tpm1 cells. Aim21 regulates the abundance of actin in cortical patches and this regulation is necessary for efficient endocytosis.
      Title: Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion migration along actin filament IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Aim21-Tda2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 

    General protein information

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    Preferred Names
    Aim21p
    NP_012268.3
    • Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      360885..362924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179525.3 → NP_012268.3  TPA: Aim21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012268.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C8ZAQ2, D6VVT3, P40563
      UniProtKB/TrEMBL
      N1P487
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40563.1

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