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    TIF2 translation initiation factor eIF4A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853303, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TIF2
    Gene description
    translation initiation factor eIF4A
    Primary source
    FungiDB:YJL138C
    Locus tag
    YJL138C
    See related
    SGD:S000003674; AllianceGenome:SGD:S000003674; VEuPathDB:YJL138C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA helicase activity and translation initiation factor activity. Involved in positive regulation of formation of translation preinitiation complex and translational initiation. Located in cytoplasmic stress granule and plasma membrane. Part of eukaryotic translation initiation factor 4F complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TIF2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (153504..154691, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II subunit RPB4 Neighboring gene mannosyltransferase YUR1 Neighboring gene glycogenin glucosyltransferase GLG2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The initiation factor eIF4A is involved in the response to lithium stress in Saccharomyces cerevisiae. Montero-Lomeli M, et al. J Biol Chem, 2002 Jun 14. PMID 11940596
    2. Molecular dynamics simulation of the allosteric regulation of eIF4A protein from the open to closed state, induced by ATP and RNA substrates. Meng H, et al. PLoS One, 2014. PMID 24465900, Free PMC Article
    3. Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast. Barhoumi M, et al. FEBS J, 2006 Nov. PMID 17087726
    4. Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase. Caruthers JM, et al. Proc Natl Acad Sci U S A, 2000 Nov 21. PMID 11087862, Free PMC Article
    5. Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase. Johnson ER, et al. RNA, 1999 Dec. PMID 10606264, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation.
      Title: mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation.
    2. Findings that eIF4A functionally interacts with the pre-initiation complex and plays important roles beyond unwinding 5'-UTR structure is consistent with a recent proposal that eIF4A modulates the conformation of the 40S ribosomal subunit to promote mRNA recruitment.
      Title: Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity.
    3. Findings suggest that Ded1 is critically required to promote scanning through secondary structures within 5' UTRs, and while eIF4A cooperates with Ded1 in this function, it also promotes a step of initiation common to virtually all yeast mRNAs.
      Title: Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.
    4. Overexpression of the translation initiation factor TIF2 increases the induction of HXT1 translation.
      Title: Expression of the glucose transporter HXT1 involves the Ser-Thr protein phosphatase Sit4 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of formation of translation preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    part_of eukaryotic translation initiation factor 4F complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF4A
    NP_012397.1
    • Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      153504..154691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181571.1 → NP_012397.1  TPA: translation initiation factor eIF4A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQJ1, D6VW46, P10081
      UniProtKB/TrEMBL
      A0A6A5PVK4, B3LRD4, C8ZCM2, G2WI87, N1P0H0, N1P0I8
      Conserved Domains (1) summary
      PTZ00424
      Location:10 → 394
      PTZ00424; helicase 45; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10081.3

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