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    ERG20 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853272, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ERG20
    Primary source
    SGD:S000003703
    Locus tag
    YJL167W
    See related
    AllianceGenome:SGD:S000003703; FungiDB:YJL167W; VEuPathDB:YJL167W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BOT3; FDS1; FPP1
    Summary
    Enables dimethylallyltranstransferase activity and geranyltranstransferase activity. Involved in ergosterol biosynthetic process and farnesyl diphosphate biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (105014..106072)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Asg7p Neighboring gene histone methyltransferase SET2 Neighboring gene ubiquinol--cytochrome-c reductase subunit 8 Neighboring gene protein kinase HAL5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids. Dusséaux S, et al. Proc Natl Acad Sci U S A, 2020 Dec 15. PMID 33268495, Free PMC Article
    2. High-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm. Zhang Y, et al. Enzyme Microb Technol, 2020 Mar. PMID 32044019
    3. Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone. Meng X, et al. Microb Cell Fact, 2020 Feb 3. PMID 32013959, Free PMC Article
    4. Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase. Rubat S, et al. FEMS Yeast Res, 2017 Jun 1. PMID 28854674
    5. Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase. Ignea C, et al. Metab Eng, 2015 Jan. PMID 25446975

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dimethylallyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dimethylallyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geranyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables geranyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables geranyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in geranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
    NP_012368.1
    • Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      105014..106072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181600.1 → NP_012368.1  TPA: bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW20, P08524, P15495
      UniProtKB/TrEMBL
      A6ZQG5, B3LPV6, B5VL19, C7GRZ5, C8ZB52, G2WGK6
      Conserved Domains (1) summary
      pfam00348
      Location:38 → 305
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08524.2

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