HAM1 nucleoside triphosphate pyrophosphohydrolase HAM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HAM1
Gene description: nucleoside triphosphate pyrophosphohydrolase HAM1
Primary source: FungiDB:YJR069C
Locus tag: YJR069C
See related: SGD:S000003830; AllianceGenome:SGD:S000003830; VEuPathDB:YJR069C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nucleoside-triphosphate diphosphatase activity. Involved in purine deoxyribonucleoside triphosphate catabolic process and pyrimidine deoxyribonucleoside triphosphate catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); developmental and epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HAM1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (568806..569399, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine utilization and interconversion in yeast make the greatest contribution to the system of protection against the toxic and mutagenic action of the examined analogs.
Title: [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae].

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ITP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ITP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables UTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables XTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables XTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables dATP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dCTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dGTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dITP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dITP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables dTTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables dUTP diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside triphosphate diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleoside triphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine deoxyribonucleoside triphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in purine deoxyribonucleoside triphosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine deoxyribonucleoside triphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine deoxyribonucleoside triphosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside triphosphate pyrophosphohydrolase HAM1

NP_012603.1

EC 3.6.1.9

Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

568806..569399 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181727.1 → NP_012603.1 TPA: nucleoside triphosphate pyrophosphohydrolase HAM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012603.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWP0, P47119

UniProtKB/TrEMBL

A0A6A5PYT3, A6ZQ28, B3LQF6, B5VLM2, C7GMD4, C8ZBL7, G2WH74, N1P150

Conserved Domains (1) summary

cd00515
Location:6 → 191

HAM1; NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A ...