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    YKL107W putative short-chain dehydrogenase/reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853753, updated on 1-Aug-2024

    Summary

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    Gene symbol
    YKL107W
    Gene description
    putative short-chain dehydrogenase/reductase
    Primary source
    FungiDB:YKL107W
    Locus tag
    YKL107W
    See related
    SGD:S000001590; AllianceGenome:SGD:S000001590; VEuPathDB:YKL107W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity. Involved in response to furfural. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YKL107W in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (236141..237070)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene transcription factor HAP4 Neighboring gene Sld2p Neighboring gene uncharacterized protein Neighboring gene aspartate transaminase AAT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YKL107W from Saccharomyces cerevisiae encodes a novel aldehyde reductase for detoxification of acetaldehyde, glycolaldehyde, and furfural. Wang H, et al. Appl Microbiol Biotechnol, 2019 Jul. PMID 31115629
    2. The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast. Chéret G, et al. Yeast, 1993 Nov. PMID 8109175
    3. Genetic and proteomic evidences support the localization of yeast enolase in the cell surface. López-Villar E, et al. Proteomics, 2006 Apr. PMID 16544286
    4. Unstable tandem repeats in promoters confer transcriptional evolvability. Vinces MD, et al. Science, 2009 May 29. PMID 19478187, Free PMC Article
    5. The ubiquitin-proteasome system regulates meiotic chromosome organization. Yang X, et al. Proc Natl Acad Sci U S A, 2022 Apr 26. PMID 35439061, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to furfural IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative short-chain dehydrogenase/reductase
    NP_012815.1
    • NADH-dependent aldehyde reductase; involved in the detoxification of acetaldehyde, glycolaldehyde, furfural, formaldehyde and propionaldehyde; localizes to the endoplasmic reticulum; member of the classical short-chain dehydrogenase/reductase (SDR) family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      236141..237070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179673.1 → NP_012815.1  TPA: putative short-chain dehydrogenase/reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXI0, P34251
      UniProtKB/TrEMBL
      A6ZZK9, C7GVK3, C8ZC68, G2WHS6, N1NZ31
      Conserved Domains (1) summary
      cl21454
      Location:26 → 285
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34251.1

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