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    MIC60 Mic60p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853886, updated on 4-Aug-2024

    Summary

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    Gene symbol
    MIC60
    Gene description
    Mic60p
    Primary source
    FungiDB:YKR016W
    Locus tag
    YKR016W
    See related
    SGD:S000001724; AllianceGenome:SGD:S000001724; VEuPathDB:YKR016W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM28; FCJ1; FMP13
    Summary
    Involved in cristae formation and protein import into mitochondrial intermembrane space. Located in mitochondrial crista and mitochondrial crista junction. Part of MICOS complex. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MIC60 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (469717..471339)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Rab family GTPase YPT52 Neighboring gene uncharacterized protein Neighboring gene E3 ubiquitin-protein ligase HEL1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Central role of Mic10 in the mitochondrial contact site and cristae organizing system. Bohnert M, et al. Cell Metab, 2015 May 5. PMID 25955210
    2. The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria. Körner C, et al. Mol Biol Cell, 2012 Jun. PMID 22496419, Free PMC Article
    3. Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. Rabl R, et al. J Cell Biol, 2009 Jun 15. PMID 19528297, Free PMC Article
    4. Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria. Stoldt S, et al. Proc Natl Acad Sci U S A, 2019 May 14. PMID 31028145, Free PMC Article
    5. Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport. Kojima R, et al. Cell Rep, 2019 Jan 15. PMID 30650346, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Fcj1 and Mos1 are required for maintaining mitochondrial DNA (mtDNA) nucleoid size.
      Title: Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology.
    2. the intermembrane space domains of mitofilin play distinct roles in interactions with outer membrane complexes and maintenance of MINOS and cristae morphology.
      Title: Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains.
    3. Results propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F(1)F(O) oligomeric state, thereby controlling membrane curvature of cristae to generate crista junctions and cristae tips.
      Title: Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial intermembrane space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial intermembrane space IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial crista IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial crista junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mic60p
    NP_012941.1
    • Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      469717..471339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179806.1 → NP_012941.1  TPA: Mic60p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012941.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZY0, B3LRA0, D6VX81, P36112
      UniProtKB/TrEMBL
      N1P0V5
      Conserved Domains (1) summary
      pfam09731
      Location:130 → 533
      Mitofilin; Mitochondrial inner membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36112.1

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