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    ALY1 Aly1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853891, updated on 1-Aug-2024

    Summary

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    Gene symbol
    ALY1
    Gene description
    Aly1p
    Primary source
    FungiDB:YKR021W
    Locus tag
    YKR021W
    See related
    SGD:S000001729; AllianceGenome:SGD:S000001729; VEuPathDB:YKR021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ART6
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in endocytosis; positive regulation of ubiquitin-dependent endocytosis; and regulation of intracellular transport. Located in early endosome and late endosome. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ALY1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (479234..481981)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Irs4p Neighboring gene Vps51p Neighboring gene Ntr2p Neighboring gene Rqt4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2. Hatakeyama R, et al. Mol Cell Biol, 2010 Dec. PMID 20956561, Free PMC Article
    2. FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition. Barthelemy C, et al. Sci Rep, 2017 Oct 23. PMID 29062000, Free PMC Article
    3. Proteomic and genetic analysis of the response of S. cerevisiae to soluble copper leads to improvement of the antimicrobial function of cellulosic copper nanoparticles. Rong-Mullins X, et al. Metallomics, 2017 Sep 20. PMID 28869270, Free PMC Article
    4. Alpha-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling. O'Donnell AF, et al. Mol Biol Cell, 2010 Oct 15. PMID 20739461, Free PMC Article
    5. Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors. Wawrzycka D, et al. Biochim Biophys Acta Biomembr, 2019 May 1. PMID 30776335

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dephosphorylation of Aly1 by calcineurin serves as a regulatory switch to promote Aly1-mediated trafficking to the vacuole.
      Title: A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ubiquitin-dependent endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of intracellular pH IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aly1p
    NP_012946.3
    • Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; regulates intracellular pH; ALY1 has a paralog, ALY2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      479234..481981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179811.4 → NP_012946.3  TPA: Aly1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012946.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX86, P36117
      UniProtKB/TrEMBL
      B5VMG9, G2WI52
      Conserved Domains (1) summary
      smart01017
      Location:347 → 517
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36117.1

    Gene LinkOut

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