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    SAP190 Sap190p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853899, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAP190
    Official Full Name
    Sap190p
    Primary source
    SGD:S000001736
    Locus tag
    YKR028W
    See related
    AllianceGenome:SGD:S000001736; FungiDB:YKR028W; VEuPathDB:YKR028W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein phosphatase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; TOR signaling; and tRNA wobble uridine modification. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SAP190 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (494257..497358)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene Bch2p Neighboring gene histone-binding protein SET3 Neighboring gene Gmh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Jablonowski D, et al. Genetics, 2001 Dec. PMID 11779790, Free PMC Article
    2. The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Lockshon D, et al. Genetics, 2007 Jan. PMID 17151231, Free PMC Article
    3. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
    4. Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae. Hood-DeGrenier JK. Yeast, 2011 Mar. PMID 21360731
    5. The yeast elongator histone acetylase requires Sit4-dependent dephosphorylation for toxin-target capacity. Jablonowski D, et al. Mol Biol Cell, 2004 Mar. PMID 14718557, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sap190p
    NP_012953.2
    • Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      494257..497358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179818.2 → NP_012953.2  TPA: Sap190p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012953.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5VMH6, D6VX93, P36123
      UniProtKB/TrEMBL
      N1NZG5
      Conserved Domains (1) summary
      pfam04499
      Location:266 → 762
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36123.2

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