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    YBT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850678, updated on 11-Sep-2024

    Summary

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    Official Symbol
    YBT1
    Primary source
    SGD:S000003971
    Locus tag
    YLL048C
    See related
    AllianceGenome:SGD:S000003971; FungiDB:YLL048C; VEuPathDB:YLL048C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BAT1
    Summary
    Enables ATPase-coupled monocarboxylic acid transmembrane transporter activity. Involved in monocarboxylic acid transport. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC1 (ATP binding cassette subfamily C member 1); ABCC2 (ATP binding cassette subfamily C member 2); and ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (41280..46265, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cofilin Neighboring gene Ldb18p Neighboring gene Rnp1p Neighboring gene ribosomal 60S subunit protein L8B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast. Khandelwal NK, et al. Antimicrob Agents Chemother, 2019 Mar. PMID 30642932, Free PMC Article
    2. The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation. Sasser TL, et al. Biochem J, 2012 Dec 15. PMID 22970809, Free PMC Article
    3. A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. Ortiz DF, et al. J Biol Chem, 1997 Jun 13. PMID 9182565
    4. The glutathione-mediated detoxification pathway in yeast: an analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes. Sharma KG, et al. Arch Microbiol, 2003 Aug. PMID 12819858
    5. Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2. Rebbeor JF, et al. Biochim Biophys Acta, 2002 Feb 15. PMID 11853683

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of YBT1 enhances in vitro homotypic vacuole fusion by up to 50% relative to wild-type vacuoles.
      Title: The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation.
    2. Data show that Ybt1 is required to import the phosphatidylcholine (PC) analog NBD-PC (7-nitro-2,1,3-benzoxadiazol-PC) into vacuoles in the presence of ATP in vitro.
      Title: Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monocarboxylic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocarboxylic acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bile acid-transporting ATPase YBT1
    NP_013052.1
    • Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      41280..46265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181868.1 → NP_013052.1  TPA: bile acid-transporting ATPase YBT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXW0, P32386, Q07882
      UniProtKB/TrEMBL
      C7GNE7
      Conserved Domains (1) summary
      TIGR00957
      Location:353 → 1639
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32386.2

    Gene LinkOut

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