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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855615, updated on 18-Sep-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000005052
    Locus tag
    YNL108C
    See related
    AllianceGenome:SGD:S000005052; FungiDB:YNL108C; VEuPathDB:YNL108C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HUF
    Summary
    Enables phosphatase activity. Involved in dephosphorylation. Located in cytoplasm and nucleus. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A) and UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (419014..419826, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Cyb5p Neighboring gene rRNA-binding ribosome biosynthesis protein NOP15 Neighboring gene YEATS domain-containing protein YAF9 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detection of modifications in the glucose metabolism induced by genetic mutations in Saccharomyces cerevisiae by 13C- and H-NMR spectroscopy. Herve M, et al. Eur J Biochem, 2000 Jun. PMID 10824121
    2. Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. Taylor NM, et al. J Biol Chem, 2013 May 24. PMID 23569204, Free PMC Article
    3. A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95. Manaud N, et al. Mol Cell Biol, 1998 Jun. PMID 9584160, Free PMC Article
    4. Gene disruption and basic phenotypic analysis of nine novel yeast genes from chromosome XIV. Capozzo C, et al. Yeast, 2000 Sep 15. PMID 10953080
    5. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tau55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities, and provide a small set of regulated phosphosite targets in vivo.
      Title: Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_014291.1
    • Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      419014..419826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182946.1 → NP_014291.1  TPA: uncharacterized protein YNL108C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W172, P53929
      UniProtKB/TrEMBL
      A6ZRX3, B3LNW6, C7GKD5, C8ZGC2, G2WLZ7, N1NXF9
      Conserved Domains (1) summary
      COG0406
      Location:5 → 227
      PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53929.1

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