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    RPC19 DNA-directed RNA polymerase core subunit RPC19 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855609, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RPC19
    Gene description
    DNA-directed RNA polymerase core subunit RPC19
    Primary source
    FungiDB:YNL113W
    Locus tag
    YNL113W
    See related
    SGD:S000005057; AllianceGenome:SGD:S000005057; VEuPathDB:YNL113W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase I activity and RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPC19 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (412771..413199)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating protein DMA2 Neighboring gene uncharacterized protein Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene Cyb5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reconstitution of yeast and Arabidopsis RNA polymerase alpha-like subunit heterodimers. Larkin RM, et al. J Biol Chem, 1997 May 9. PMID 9139743
    2. RPC19, the gene for a subunit common to yeast RNA polymerases A (I) and C (III). Dequard-Chablat M, et al. J Biol Chem, 1991 Aug 15. PMID 1869554
    3. Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity. Walker-Kopp N, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973381, Free PMC Article
    4. Rpc19 and Rpc40, two alpha-like subunits shared by nuclear RNA polymerases I and III, are interchangeable between the fission and budding yeasts. Shpakovski GV, et al. Curr Genet, 1999 Oct. PMID 10541858
    5. The fission yeast rpa17+ gene encodes a functional homolog of AC19, a subunit of RNA polymerases I and III of Saccharomyces cerevisiae. Imai K, et al. Mol Gen Genet, 1999 Mar. PMID 10102372

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase core subunit RPC19
    NP_014286.1
    • RNA polymerase subunit AC19; common to RNA polymerases I and III

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      412771..413199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182951.1 → NP_014286.1  TPA: DNA-directed RNA polymerase core subunit RPC19 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W168, P28000
      UniProtKB/TrEMBL
      A0A6A5Q5H1, A6ZRW9, B3LNX1, C7GKD1, C8ZGB7, G2WLZ3, N1NWJ5
      Conserved Domains (1) summary
      cd07029
      Location:52 → 135
      RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28000.1

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