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    SPC98 Spc98p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855597, updated on 1-Aug-2024

    Summary

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    Gene symbol
    SPC98
    Gene description
    Spc98p
    Primary source
    FungiDB:YNL126W
    Locus tag
    YNL126W
    See related
    SGD:S000005070; AllianceGenome:SGD:S000005070; VEuPathDB:YNL126W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables gamma-tubulin binding activity. Involved in microtubule nucleation and mitotic spindle organization. Located in inner plaque of spindle pole body and outer plaque of spindle pole body. Part of gamma-tubulin small complex. Orthologous to human TUBGCP3 (tubulin gamma complex associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPC98 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (387227..389767)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Neighboring gene Far11p Neighboring gene Esbp6p Neighboring gene RNA-binding snoRNP assembly protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Components of the yeast spindle and spindle pole body. Rout MP, et al. J Cell Biol, 1990 Nov. PMID 2229181, Free PMC Article
    2. Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM. Choy RM, et al. J Struct Biol, 2009 Dec. PMID 19723581, Free PMC Article
    3. The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment. Geissler S, et al. EMBO J, 1996 Aug 1. PMID 8670895, Free PMC Article
    4. CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Brilot AF, et al. Elife, 2021 May 5. PMID 33949948, Free PMC Article
    5. Structure of γ-tubulin small complex based on a cryo-EM map, chemical cross-links, and a remotely related structure. Greenberg CH, et al. J Struct Biol, 2016 Jun. PMID 26968363, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables gamma-tubulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in equatorial microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin small complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin small complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in inner plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc98p
    NP_014273.1
    • Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      387227..389767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182964.1 → NP_014273.1  TPA: Spc98p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014273.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W157, P53540
      UniProtKB/TrEMBL
      B3LNY2, B5VQS2, N1NZC8
      Conserved Domains (2) summary
      pfam04130
      Location:476 → 823
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:185 → 467
      GCP_N_terminal; Gamma tubulin complex component N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53540.1

    Gene LinkOut

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