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    TEP1 putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855595, updated on 1-Aug-2024

    Summary

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    Gene symbol
    TEP1
    Gene description
    putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
    Primary source
    FungiDB:YNL128W
    Locus tag
    YNL128W
    See related
    SGD:S000005072; AllianceGenome:SGD:S000005072; VEuPathDB:YNL128W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein tyrosine phosphatase activity. Involved in ascospore wall assembly. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); gastrointestinal system cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TEP1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (382359..383663)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Dgr1p Neighboring gene ribosylnicotinamide kinase Neighboring gene Far11p Neighboring gene Spc98p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast. Cid VJ, et al. Oncogene, 2008 Sep 18. PMID 18794878
    2. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Heymont J, et al. Proc Natl Acad Sci U S A, 2000 Nov 7. PMID 11070083, Free PMC Article
    3. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. Mitra P, et al. J Cell Biol, 2004 Jul 19. PMID 15249580, Free PMC Article
    4. Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Rodríguez-Escudero I, et al. Biochem J, 2005 Sep 1. PMID 15913452, Free PMC Article
    5. Identification of putative negative regulators of yeast signaling through a screening for protein phosphatases acting on cell wall integrity and mating MAPK pathways. Sacristán-Reviriego A, et al. Fungal Genet Biol, 2015 Apr. PMID 25736922

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
    NP_014271.3
    • PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      382359..383663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182966.4 → NP_014271.3  TPA: putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014271.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W155, P53916
      UniProtKB/TrEMBL
      A6ZRV6, B3LNY4, C7GKB8, C8ZGA3, N1P4B5
      Conserved Domains (1) summary
      cd14497
      Location:43 → 251
      PTP_PTEN-like; protein tyrosine phosphatase-like domain of phosphatase and tensin homolog and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53916.1

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