NRK1 ribosylnicotinamide kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: NRK1
Gene description: ribosylnicotinamide kinase
Primary source: FungiDB:YNL129W
Locus tag: YNL129W
See related: SGD:S000005073; AllianceGenome:SGD:S000005073; VEuPathDB:YNL129W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ribosylnicotinamide kinase activity. Involved in NAD biosynthesis via nicotinamide riboside salvage pathway and nicotinamide riboside metabolic process. Located in fungal-type vacuole. Orthologous to human NMRK1 (nicotinamide riboside kinase 1) and NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NRK1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (381480..382202)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanism of action of nicotinamide riboside is totally dependent on increased net NAD synthesis through two pathways, the Nrk1 pathway and the Urh1/Pnp1/Meu1 pathway, which is Nrk1 independent.
Title: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribosylnicotinamide kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosylnicotinamide kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosylnicotinamide kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nicotinamide riboside metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nicotinamide riboside metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: ribosylnicotinamide kinase

NP_014270.1

EC 2.7.1.173

EC 2.7.1.22

Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

381480..382202

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182967.1 → NP_014270.1 TPA: ribosylnicotinamide kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014270.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W154, P53915

UniProtKB/TrEMBL

A0A8H4F968, A6ZRV5, B3LNY5, B5VQR8, C7GKB7, C8ZGA2, G2WLX8, N1NWI6

Conserved Domains (1) summary

cd02024
Location:8 → 198

NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...