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    DUF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854066, updated on 11-Sep-2024

    Summary

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    Official Symbol
    DUF1
    Primary source
    SGD:S000005447
    Locus tag
    YOL087C
    See related
    AllianceGenome:SGD:S000005447; FungiDB:YOL087C; VEuPathDB:YOL087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin binding activity. Predicted to be involved in double-strand break repair via homologous recombination and protein deubiquitination. Located in cytoplasm. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (155287..158637, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hal9p Neighboring gene protein disulfide isomerase MPD2 Neighboring gene Mhf1p Neighboring gene alcohol dehydrogenase ADH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemotyping of yeast mutants using robotics. Rieger KJ, et al. Yeast, 1999 Jul. PMID 10407277
    2. Construction of PCR-ligated long flanking homology cassettes for use in the functional analysis of six unknown open reading frames from the left and right arms of Saccharomyces cerevisiae chromosome XV. Pearson BM, et al. Yeast, 1998 Mar 15. PMID 9559547
    3. A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. Kanga S, et al. PLoS One, 2012. PMID 22723847, Free PMC Article
    4. WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Pashkova N, et al. Mol Cell, 2010 Nov 12. PMID 21070969, Free PMC Article
    5. Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins. Konduri PC, et al. Cells, 2020 Mar 22. PMID 32235736, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Duf1p
    NP_014554.1
    • Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      155287..158637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183341.1 → NP_014554.1  TPA: Duf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Y1, Q99247
      UniProtKB/TrEMBL
      N1NWC4
      Conserved Domains (3) summary
      sd00039
      Location:165 → 207
      7WD40; WD40 repeat [structural motif]
      cd17041
      Location:1018 → 1098
      Ubl_WDR48; Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins
      cl29593
      Location:10 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99247.1

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